InterPro domain: IPR005016
General Information
- Identifier IPR005016
- Description Serine incorporator/TMS membrane protein
- Number of genes 592
- Gene duplication stats Loading...
- Associated GO terms GO:0016020
Abstract
The serine incorporator/TMS membrane protein (TDE1/TMS) family include SERINC1-5 from mammals and membrane protein Tms1 from budding yeasts. Members in this family contain eleven transmembrane helices.
SERINC1-5 function in incorporating serine into membranes and facilitating the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids [ 1 ]. Serinc3 (also known as TDE1) is overexpressed in tumours [ 2 ].
The function of Tms1 is not clear.
1. Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis. J. Biol. Chem. 280, 35776-83
2. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. Oncogene 25, 4549-58
Species distribution
Gene table
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