InterPro domain: IPR005011
General Information
- Identifier IPR005011
- Description SNU66/SART1 family
- Number of genes 205
- Gene duplication stats Loading...
- Associated GO terms GO:0000398
Abstract
This entry represents U4/U6.U5 tri-snRNP-associated proteins, including SART1 from animals, Snu66 from yeasts and DOT2 from Arabidopsis.
SART1 and its yeast homologue, Snu66, are part of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome [ 1 , 2 , 3 ]. DOT2 plays a role in root, shoot and flower development [ 4 , 5 ].
1. The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes. EMBO J. 20, 2553-63
2. Purification of the yeast U4/U6.U5 small nuclear ribonucleoprotein particle and identification of its proteins. Proc. Natl. Acad. Sci. U.S.A. 96, 7226-31
3. Ubiquitin-like protein Hub1 is required for pre-mRNA splicing and localization of an essential splicing factor in fission yeast. Curr. Biol. 14, 2283-8
4. MERISTEM-DEFECTIVE, an RS domain protein, is required for the correct meristem patterning and function in Arabidopsis. Plant J. 57, 857-69
5. Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana. Plant J. 56, 251-63