InterPro domain: IPR004854
General Information
- Identifier IPR004854
- Description Ubiquitin fusion degradation protein Ufd1-like
- Number of genes 460
- Gene duplication stats Loading...
- Associated GO terms GO:0006511
Abstract
This entry includes Ubiquitin fusion degradation protein Ufd1 from fungi and Ufd1-like proteins from animals and plants.
Ufd1 is part of the Ufd1-Npl4 complex that functions as the substrate-recruiting cofactor for Cdc48 segregase. The Cdc48-Ufd1-Npl4 complex is involved in degradation of misfolded ER proteins [ 1 ]. The Ufd1-Npl4 complex has been found to recruit Cdc48 to ubiquitylated CMG (Cdc45-MCM-GINS) helicase at the end of chromosome replication, thereby driving the disassembly reaction [ 2 ].
In humans, Npl4-Ufd1 acts as a cofactor in reducing antiviral innate immune responses by facilitating proteasomal degradation of RIG-I (a viral RNA sensor) [ 3 ].
1. The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase. Biochem. Biophys. Res. Commun. 394, 335-41
2. Ufd1-Npl4 Recruit Cdc48 for Disassembly of Ubiquitylated CMG Helicase at the End of Chromosome Replication. Cell Rep 18, 3033-3042
3. A non-canonical role of the p97 complex in RIG-I antiviral signaling. EMBO J. 34, 2903-20