InterPro domain: IPR004837

General Information

  • Identifier IPR004837
  • Description Sodium/calcium exchanger membrane region
  • Number of genes 1735
  • Gene duplication stats Loading...
  • Associated GO terms GO:0055085   GO:0016021  

Abstract

The sodium/calcium exchangers are a family of integral membrane proteins. This domain covers the integral membrane regions of these proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells [ 1 ]. Ca2+ is moved into or out of the cytosol depending on Na+ concentration [ 2 ]. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3 [ 2 ].


1. Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science 250, 562-5
2. Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. J. Biol. Chem. 271, 24914-21

Species distribution

Gene table