InterPro domain: IPR004523
General Information
- Identifier IPR004523
- Description Aspartate-tRNA synthetase, type 2
- Number of genes 248
- Gene duplication stats Loading...
- Associated GO terms GO:0000166 GO:0005524 GO:0005737 GO:0004815 GO:0006422
Abstract
Aspartyl tRNA synthetase is an alpha2 dimer that belongs to class IIb. Structural analysis combined with mutagenesis and enzymology data on the yeast enzyme point to a tRNA binding process that starts by a recognition event between the tRNA anticodon loop and the synthetase anticodon binding module [ 1 ].
This family represents a group of aspartyl-tRNA synthetases from the eukaryotic cytosol, from archaea and from some bacteria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA (asn) is subsequently transamidated to Asn-tRNA (asn).
1. The free yeast aspartyl-tRNA synthetase differs from the tRNA(Asp)-complexed enzyme by structural changes in the catalytic site, hinge region, and anticodon-binding domain. J. Mol. Biol. 299, 1313-24