InterPro domain: IPR004405
General Information
- Identifier IPR004405
- Description Translation release factor pelota
- Number of genes 221
- Gene duplication stats Loading...
- Associated GO terms GO:0070481 GO:0071025 GO:0070966
Abstract
Pelota (known as DOM34 in yeast) binds Hbs1, which is EF1-alpha-related subfamily GTPase, and is considered to play a crucial role in mRNA surveillance for protein synthesis [ 1 ]. It is involved in No-go decay (NGD) and non-stop decay (NSD) surveillance mechanisms that target mRNAs on which elongation complexes are stalled. Pelota/Hbs1 were shown to promote dissociation of stalled elongation complexes and release of intact peptidyl-tRNA in the presence of the ATP-binding cassette protein ABCE1 [ 2 ]. Pelota is conserved in eukaryotes and archaea [ 3 ].
1. RNA quality control in eukaryotes. Cell 131, 660-8
2. Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes. EMBO J. 30, 1804-17
3. Omnipotent role of archaeal elongation factor 1 alpha (EF1α in translational elongation and termination, and quality control of protein synthesis. Proc. Natl. Acad. Sci. U.S.A. 107, 19242-7