InterPro domain: IPR003293

This entry represents several nudix hydrolases, including nudix hydrolase 2, 5, 6, 7, 8 and 10. Nudix hydrolases are ubiquitous proteins that hydrolyse a wide range of organic pyrophosphates, including nucleoside di- and triphosphates, dinucleoside and diphosphoinositol polyphosphates, nucleotide sugars and RNA caps, with varying degrees of substrate specificity [ 1 ]. Nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis [ 2 ].

1. The Nudix hydrolase superfamily. Cell. Mol. Life Sci. 63, 123-43
2. The nudix hydrolase 7 is an Acyl-CoA diphosphatase involved in regulating peroxisomal coenzyme A homeostasis. J. Biochem. 144, 655-63