InterPro domain: IPR003165

General Information

  • Identifier IPR003165
  • Description Piwi domain
  • Number of genes 1507
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003676  

Abstract

The piwi domain [ 1 ] is a protein domain found in piwi proteins and a large number of related nucleic acid-binding proteins, especially those that bind and cleave RNA. The function of the domain is double stranded-RNA-guided hydrolysis of single stranded-RNA, as has been determined in the argonaute family of related proteins [ 2 ].


1. Domains in gene silencing and cell differentiation proteins: the novel PAZ domain and redefinition of the Piwi domain. Trends Biochem. Sci. 25, 481-2
2. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305, 1434-7

Species distribution

Gene table