InterPro domain: IPR002816
General Information
- Identifier IPR002816
- Description TraB/PrgY/GumN family
- Number of genes 324
- Gene duplication stats Loading...
Abstract
This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture -cobbled from the folds of the EreA/ChaN/PMT group- that mediates proteolytic activities [ 1 ].
Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors [ 2 ].
TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone [ 3 ].
1. The TIKI/TraB/PrgY family: a common protease fold for cell signaling from bacteria to metazoa? Dev. Cell 25, 225-7
2. Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation. Cell 149, 1565-77