InterPro domain: IPR002591

This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1/alkaline phosphodiesterase I/nucleotide pyrophosphatase (nppase). These enzymes catalyze the cleavage of phosphodiester and phosphosulphate bonds in NAD, deoxynucleotides and nucleotide sugars [ 1 , 2 ]. Another member of this family is ATX an autotaxin, tumor cell motility-stimulating protein which exhibits type I phosphodiesterases activity [ 3 , 4 ]. The alignment encompasses the active site [ 5 , 6 ]. Also present within this family is 60kDa Ca2-ATPase from Myroides odoratus [ 6 ].

This entry also hits a number of ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis [ 7 , 8 ].

1. Molecular cloning and chromosomal localization of PD-Ibeta (PDNP3), a new member of the human phosphodiesterase I genes. Genomics 45, 412-5
2. Structural basis for nucleotide recognition by the ectoenzyme CD203c. FEBS J 285, 2481-2494
3. cDNA cloning of the human tumor motility-stimulating protein, autotaxin, reveals a homology with phosphodiesterases. J. Biol. Chem. 269, 30479-84
4. Identification of human plasma lysophospholipase D, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase. J Biol Chem 277, 39436-42
5. Affinity purification and cDNA cloning of rat neural differentiation and tumor cell surface antigen gp130RB13-6 reveals relationship to human and murine PC-1. J. Biol. Chem. 270, 9849-55
6. Cloning and expression of the unique Ca2+-ATPase from Flavobacterium odoratum. J. Biol. Chem. 271, 5095-100
7. GPI7 is the second partner of PIG-F and involved in modification of glycosylphosphatidylinositol. J. Biol. Chem. 280, 9728-34
8. Phenotype-genotype correlations of PIGO deficiency with variable phenotypes from infantile lethality to mild learning difficulties. Hum. Mutat. 38, 805-815