InterPro domain: IPR002480
General Information
- Identifier IPR002480
- Description DAHP synthetase, class II
- Number of genes 449
- Gene duplication stats Loading...
- Associated GO terms GO:0009073 GO:0003849
Abstract
Members of the 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthetase family ( 2.5.1.54 ) catalyse the first step in aromatic amino acid biosynthesis from chorismate. Class I (see IPR006218 ) includes bacterial and yeast enzymes; class II includes higher plants and various microorganisms [ 1 ].
The first step in the common pathway leading to the biosynthesis of aromatic compounds is the stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). This reaction is catalyzed by DAHP synthase, a metal-activated enzyme, which in microorganisms is the target for negative-feedback regulation by pathway intermediates or by end products.
1. Evidence for a novel class of microbial 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase in Streptomyces coelicolor A3(2), Streptomyces rimosus and Neurospora crassa. Microbiology (Reading, Engl.) 142 ( Pt 8), 1973-82