InterPro domain: IPR001179

General Information

  • Identifier IPR001179
  • Description FKBP-type peptidyl-prolyl cis-trans isomerase domain
  • Number of genes 2569
  • Gene duplication stats Loading...
  • Associated GO terms GO:0003755  

Abstract

FKBP-type peptidylprolyl isomerases ( 5.2.1.8 ) in vertebrates, are receptors for the two immunosuppressants, FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides. These proteins are found in a variety of organisms [ 1 ].

This entry represents a domain found in FKBP-type peptidylprolyl isomerases.


1. Molecular insights into substrate recognition and catalytic mechanism of the chaperone and FKBP peptidyl-prolyl isomerase SlyD. BMC Biol. 14, 82

Species distribution

Gene table