InterPro domain: IPR001155
General Information
- Identifier IPR001155
- Description NADH:flavin oxidoreductase/NADH oxidase, N-terminal
- Number of genes 922
- Gene duplication stats Loading...
- Associated GO terms GO:0010181 GO:0016491
Abstract
The TIM-barrel fold is a closed barrel structure composed of an eight-fold repeat of beta-alpha units, where the eight parallel beta strands on the inside are covered by the eight alpha helices on the outside [ 1 ]. It is a widely distributed fold which has been found in many enzyme families that catalyse completely unrelated reactions [ 2 ]. The active site is always found at the C-terminal end of this domain.
Proteins in this entry are a variety of NADH:flavin oxidoreductase/NADH oxidase enzymes, found mostly in bacteria or fungi, that contain a TIM-barrel fold. They commonly use FMN/FAD as cofactor and include:
- dimethylamine dehydrogenase
- trimethylamine dehydrogenase
- 12-oxophytodienoate reductase
- NADPH dehydrogenase
- NADH oxidase
1. The TIM-barrel fold: a versatile framework for efficient enzymes. FEBS Lett. 492, 193-8
2. One fold with many functions: the evolutionary relationships between TIM barrel families based on their sequences, structures and functions. J. Mol. Biol. 321, 741-65