InterPro domain: IPR001135
General Information
- Identifier IPR001135
- Description NADH-quinone oxidoreductase, subunit D
- Number of genes 452
- Gene duplication stats Loading...
- Associated GO terms GO:0048038 GO:0051287 GO:0016651
Abstract
This entry represents the subunit D (NuoD) of NADH-quinone oxidoreductase ( 1.6.99.5 ) and the subunit H (NdhH) of NAD(P)H-quinone oxidoreductase ([intenz:1.6.5.-]). NADH-quinone (Q) oxidoreductase is a large and complex redox proton pump, which utilises the free energy derived from oxidation of NADH with lipophilic electron/proton carrier Q to translocate protons across the membrane to generate an electrochemical proton gradient [ 1 ]. Subunit D (NuoD) is a 49kDa polypeptide that appears to be evolutionarily important in determining the physiological function of complex I/NDH-1 [ 2 ].
1. The origin of cluster N2 of the energy-transducing NADH-quinone oxidoreductase: comparisons of phylogenetically related enzymes. J. Bioenerg. Biomembr. 33, 213-22