InterPro domain: IPR001095
General Information
- Identifier IPR001095
- Description Acetyl-CoA carboxylase, alpha subunit
- Number of genes 236
- Gene duplication stats Loading...
- Associated GO terms GO:0003989 GO:0006633 GO:0009317
Abstract
This entry contains the alpha subunit the acetyl coenzyme A carboxylase complex ( 6.4.1.2 ). It catalyses the first step in the synthesis of long-chain fatty acids which involves the carboxylation of acetyl-CoA to malonyl-CoA. The acetyl-CoA carboxylase complex is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and two non-identical carboxyl transferase subunits (alpha and beta) in a 2:2 association [ 1 ]. The reaction involves two steps:
1. The genes encoding the two carboxyltransferase subunits of Escherichia coli acetyl-CoA carboxylase. J. Biol. Chem. 267, 16841-7
Species distribution
Gene table
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