InterPro domain: IPR000683
General Information
- Identifier IPR000683
- Description Gfo/Idh/MocA-like oxidoreductase, N-terminal
- Number of genes 577
- Gene duplication stats Loading...
- Associated GO terms GO:0000166
Abstract
This group of enzymes utilise NADP or NAD, and is known as the GFO/IDH/MOCA family (GFO: glucose--fructose oxidoreductase, IDH: inositol 2â€dehydrogenase and MOCA which catalyses a dehydrogenase reaction involved in rhizopine catabolism) in UniProtKB/Swiss-Prot, which includes enzymes that catalyse different chemical reactions such as oxidation and reduction of carbohydrates, oxidation of transâ€dihydrodiols, reduction of biliverdin and hydrolyzation of glycosidic bonds [ 1 ]. Other proteins belonging to this family include Gal80, a negative regulator for the expression of lactose and galactose metabolic genes, although it does not have enzymatic activity; and several hypothetical proteins from yeast, Escherichia coli and Bacillus subtilis.
The Gfo/Idh/MocA protein family members have very low sequence identity but the 3D structures of the proteins are very similar, consisting of two main domains: an N-terminal dinucleotide-binding domain containing a typical Rossmann fold3 and a C-terminal alpha/beta-domain participating in substrate binding and oligomerization. This entry represents the N-terminal domain [ 2 ].
1. Structural and functional features of the NAD(P) dependent Gfo/Idh/MocA protein family oxidoreductases. Protein Sci. 25, 778-86