Gene: Sopen02g039200

General Information

Description Encodes a histone 3 lysine 9 specific methyltransferase involved in the maintenance of DNA methylation. SUVH4/KYP is a SU(VAR)3-9 homolog, a SET domain protein. Known SET domain proteins are involved in epigenetic control of gene expression. There are 10 SUVH genes in Arabidopsis and members of this subfamily of the SET proteins have an additional conserved SRA domain. In kyp mutants, there is a loss of CpNpG methylation. The protein was shown to bind to methylated cytosines of CG, CNG and CNN motifs via its SRA domain but has a preference for the latter two. There is also evidence that KYP/SUVH4 might be involved in the telomerase-independent process known as Alternative Lengthening of Telomeres. | SU(VAR)3-9 homolog 4 (SUVH4) | FUNCTIONS IN: double-stranded methylated DNA binding, methyl-CpNpG binding, methyl-CpG binding, histone methyltransferase activity (H3-K9 specific), methyl-CpNpN binding | INVOLVED IN: maintenance of DNA methylation, histone methylation, peptidyl-lysine methylation, histone H3-K9 methylation | LOCATED IN: nucleus | EXPRESSED IN: 21 plant structures | EXPRESSED DURING: 11 growth stages | CONTAINS InterPro DOMAIN/s: SET domain , SRA-YDG , Pre-SET domain , Post-SET domain | BEST Arabidopsis thaliana protein match is: SU(VAR)3-9 homolog 6

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0034968	IEA	InterPro	histone lysine methylation
GO:0018022	ISO	PLAZA Integrative Orthology	peptidyl-lysine methylation	AT5G13960
GO:0016571	ISO	PLAZA Integrative Orthology	histone methylation	AT5G13960
GO:0010216	ISO	PLAZA Integrative Orthology	maintenance of DNA methylation	AT5G13960
GO:0051567	ISO	PLAZA Integrative Orthology	histone H3-K9 methylation	AT5G13960

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0008270	IEA	InterPro	zinc ion binding
GO:0018024	IEA	InterPro	histone-lysine N-methyltransferase activity
GO:0005515	IEA	InterPro	protein binding
GO:0010385	ISO	PLAZA Integrative Orthology	double-stranded methylated DNA binding	AT5G13960
GO:0010428	ISO	PLAZA Integrative Orthology	methyl-CpNpG binding	AT5G13960
GO:0010429	ISO	PLAZA Integrative Orthology	methyl-CpNpN binding	AT5G13960
GO:0046974	ISO	PLAZA Integrative Orthology	histone methyltransferase activity (H3-K9 specific)	AT5G13960
GO:0008327	ISO	PLAZA Integrative Orthology	methyl-CpG binding	AT5G13960

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005634	IEA	InterPro	nucleus

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

Mapman id	Description
50.2.1	Enzyme classification.EC_2 transferases.EC_2.1 transferase transferring one-carbon group