Gene: Sopen02g022650

General Information

Description This gene is predicted to encode a protein involved in negatively regulating salicylic acid-related defense responses and cell death programs. nsl1 mutants develop necrotic lesions spontaneously and show other features of a defense response, such as higher levels of SA and disease resistance-related transcripts, in the absence of a biotic stimulus. The NSL1 protein is predicted to have a MACPF domain, found in proteins that form a transmembrane pore in mammalian immune responses. NSL1 transcript levels do not appear to change in response to biotic stresses, but are elevated by cycloheximide in seedlings, and by sodium chloride in roots. | necrotic spotted lesions 1 (NSL1) | CONTAINS InterPro DOMAIN/s: Membrane attack complex component/perforin (MACPF) domain | BEST Arabidopsis thaliana protein match is: MAC/Perforin domain-containing protein

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0006952	IEA	InterPro	defense response
GO:0012501	IEA	InterPro	programmed cell death
GO:2000031	IEA	InterPro	regulation of salicylic acid mediated signaling pathway
GO:0052542	ISO	PLAZA Integrative Orthology	defense response by callose deposition	AT1G28380
GO:0006955	ISO	PLAZA Integrative Orthology	immune response	AT1G28380
GO:0008219	ISO	PLAZA Integrative Orthology	cell death	AT1G28380
GO:0009651	ISO	PLAZA Integrative Orthology	response to salt stress	AT1G28380
GO:0010337	ISO	PLAZA Integrative Orthology	regulation of salicylic acid metabolic process	AT1G28380
GO:0009626	ISO	PLAZA Integrative Orthology	plant-type hypersensitive response	AT1G28380

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR020864	Membrane attack complex component/perforin (MACPF) domain
IPR044663	MACPF domain-containing protein CAD1/NSL1-like

Mapman id	Description
27.2.12	Multi-process regulation.Programmed Cell Death (PCD) system.PCD regulatory protein (NSL1)