InterPro domain: IPR044663
General Information
- Identifier IPR044663
- Description MACPF domain-containing protein CAD1/NSL1-like
- Number of genes 921
- Gene duplication stats Loading...
- Associated GO terms GO:2000031 GO:0006952 GO:0012501
Abstract
This entry represents a group of plant MACPF domain-containing proteins, including CAD1 (also known as Protein CONSTITUTIVELY ACTIVATED CELL DEATH 1) and NSL1 (also known as Protein NECROTIC SPOTTED LESIONS 1) from Arabidopsis thaliana. They play a role in plant immunity acting as negative regulators of the salicylic acid (SA)-mediated pathway of programmed cell death [ 1 , 2 , 3 ].
1. The Arabidopsis gene CAD1 controls programmed cell death in the plant immune system and encodes a protein containing a MACPF domain. Plant Cell Physiol. 46, 902-12
2. Salicylic acid promotes quiescent center cell division through ROS accumulation and down-regulation of PLT1, PLT2, and WOX5. J Integr Plant Biol
3. Loss of Necrotic Spotted Lesions 1 associates with cell death and defense responses in Arabidopsis thaliana. Plant Mol. Biol. 62, 29-42