Gene: Sopen02g015870

General Information

Description Encodes one of the WPP domain-interacting proteins (WIT1/AT5G11390, WIT2/AT1G68910) required for RanGAP nuclear envelope association in root tip cells. Ran GTPase plays essential roles in multiple cellular processes, including nucleocytoplasmic transport, spindle formation, and postmitotic nuclear envelope reassembly. The cytoplasmic Ran GTPase activating protein RanGAP is critical to establish a functional RanGTP/RanGDP gradient across the nuclear envelope and is associated with the outer surface of the nuclear envelope in metazoan and higher plant cells. Arabidopsis thaliana RanGAP association with the root tip nuclear envelope requires a family of likely plant-specific nucleoporins combining coiled-coil and transmembrane domains (CC-TMD) and WPP domain-interacting proteins (WIPs). WIT1 and WIT2 have been identified as a second family of CC-TMD proteins, structurally similar, yet clearly distinct from the WIP family, that is required for RanGAP nuclear envelop association in root tip cells. | WPP domain-interacting protein 1 (WIT1) | BEST Arabidopsis thaliana protein match is: WPP domain-interacting protein 2

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005515	ISO	PLAZA Integrative Orthology	protein binding	AT5G11390

GO term	Evidence(s)	Provider(s)	Description	Source(s)
GO:0005635	ISO	PLAZA Integrative Orthology	nuclear envelope	AT5G11390

Experimental Evidence

Computational Reviewed Evidence

Electronic Evidence

InterPro	Description
IPR040060	WPP domain-interacting tail-anchored protein 1
IPR039976	WPP domain-interacting tail-anchored protein

Mapman id	Description
20.4.2.2	Cytoskeleton organisation.nuclear dynamics.nuclear movement.myosin-SUN-WIP adaptor (WIT)