InterPro domain: IPR039976
General Information
- Identifier IPR039976
- Description WPP domain-interacting tail-anchored protein
- Number of genes 260
- Gene duplication stats Loading...
Abstract
WIT1 and WIT2 are tail-anchored proteins [ 1 ] required for the nuclear envelope anchoring of RANGAP (Ran GTPase activating protein) in root tips in Arabidopsis [ 2 ]. They could be involved in determining plant nuclear shape [ 3 ] and pollen tube guidance [ 4 ].
1. The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane. J. Cell Biol. 161, 1013-9
2. Two distinct interacting classes of nuclear envelope-associated coiled-coil proteins are required for the tissue-specific nuclear envelope targeting of Arabidopsis RanGAP. Plant Cell 20, 1639-51
3. Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1. Nucleus 6, 144-53
4. SUN anchors pollen WIP-WIT complexes at the vegetative nuclear envelope and is necessary for pollen tube targeting and fertility. J. Exp. Bot. 66, 7299-307