Gene: AT5G24360

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT5G24360
  • Transcript Identifier AT5G24360.1
  • Gene Type Coding gene
  • Location Chr5 : 8316627-8319827 : positive

Gene Family Information

  • ID HOM05D002204
  • #Genes/#Species 304/98
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT5G24360.1
  • symbol IRE1-1
  • Alias ATIRE1-1,ARABIDOPSIS THALIANA INOSITOL REQUIRING 1-1,AtIRE1b,IRE1B
  • uniprot Q93VJ2

Descriptions

  • Description inositol requiring 1-1
  • Computational description inositol requiring 1-1 (IRE1-1); FUNCTIONS IN: endoribonuclease activity, producing 5'-phosphomonoesters, protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, mRNA processing; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Pyrrolo-quinoline quinone beta-propeller repeat (InterPro:IPR018391), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), KEN domain, ribonuclease activator (InterPro:IPR010513), PUG domain (InterPro:IPR006567), Quinonprotein alcohol dehydrogenase-like (InterPro:IPR011047); BEST Arabidopsis thaliana protein match is: Endoribonuclease/protein kinase IRE1-like (TAIR:AT2G17520.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016310
IEA
GOA Databasephosphorylation
GO:0002376
IEA
GOA Databaseimmune system process
GO:0036498
IBA
GOA DatabaseIRE1-mediated unfolded protein response
GO:0006468
IEA
Gene Ontologyprotein phosphorylation
GO:0006468
IEA
InterProprotein phosphorylation
GO:0030968
IGI
IEA
Gene Ontologyendoplasmic reticulum unfolded protein response1
GO:0030968
IEA
InterProendoplasmic reticulum unfolded protein response
GO:0006397
IEA
Gene OntologymRNA processing
GO:0006397
IEA
InterPromRNA processing
GO:0034263
IMP
Gene Ontologypositive regulation of autophagy in response to ER overload2
GO:0000394
IDA
Gene OntologyRNA splicing, via endonucleolytic cleavage and ligation3
GO:0008380
IEA
GOA DatabaseRNA splicing
GO:0008380
IMP
Gene OntologyRNA splicing4
GO:0009751
IMP
Gene Ontologyresponse to salicylic acid5
GO:0042742
IMP
Gene Ontologydefense response to bacterium5
GO:0034976
IEP
Gene Ontologyresponse to endoplasmic reticulum stress6
GO:0090501
IEA
GOA DatabaseRNA phosphodiester bond hydrolysis
GO:0090502
IEA
GOA DatabaseRNA phosphodiester bond hydrolysis, endonucleolytic
GO:0006914
IEA
GOA Databaseautophagy
GO:0006986
IEA
GOA Databaseresponse to unfolded protein
GO:0008152
IEA
GOA Databasemetabolic process

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0051082
IBA
GOA Databaseunfolded protein binding
GO:0016740
IEA
GOA Databasetransferase activity
GO:0004674
IBA
IEA
GOA Databaseprotein serine/threonine kinase activity
GO:0004674
IEA
InterProprotein serine/threonine kinase activity
GO:0005524
IEA
GOA DatabaseATP binding
GO:0005524
IEA
InterProATP binding
GO:0016301
IEA
GOA Databasekinase activity
GO:0004540
IEA
GOA Databaseribonuclease activity
GO:0004540
IEA
InterProribonuclease activity
GO:0004672
IEA
GOA Databaseprotein kinase activity
GO:0004672
IEA
InterProprotein kinase activity
GO:0000166
IEA
GOA Databasenucleotide binding
GO:0004521
IBA
GOA Databaseendoribonuclease activity
GO:0004521
IDA
IEA
Gene Ontologyendoribonuclease activity3
GO:0004521
IEA
InterProendoribonuclease activity
GO:0005515
IEA
InterProprotein binding
GO:0106310
IEA
Gene Ontologyprotein serine kinase activity
GO:0106311
IEA
Gene Ontologyprotein threonine kinase activity
GO:0046872
IEA
GOA Databasemetal ion binding
GO:0003824
IEA
GOA Databasecatalytic activity
GO:0016787
IEA
GOA Databasehydrolase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016021
IEA
GOA Databaseintegral component of membrane
GO:0016020
IEA
GOA Databasemembrane
GO:0005783
IEA
GOA Databaseendoplasmic reticulum
GO:0005783
IDA
Gene Ontologyendoplasmic reticulum7
GO:1990604
IBA
GOA DatabaseIRE1-TRAF2-ASK1 complex
GO:0005789
IEA
GOA Databaseendoplasmic reticulum membrane

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR000719 Protein kinase domain
IPR011047 Quinoprotein alcohol dehydrogenase-like superfamily
IPR045133 Serine/threonine-protein kinase/endoribonuclease IRE1/2-like
IPR015943 WD40/YVTN repeat-like-containing domain superfamily
IPR011009 Protein kinase-like domain superfamily
IPR010513 KEN domain
IPR038357 KEN domain superfamily
Mapman id Description
18.4.12 Protein modification.phosphorylation.bifunctional protein kinase and mRNA endoribonuclease (IRE)
27.11.1.1 Multi-process regulation.UPR (Unfolded Protein Response) signalling.IRE1-bZIP60 pathway.bifunctional protein kinase and ribonuclease (IRE1)