InterPro domain: IPR011047

Quinoprotein alcohol dehydrogenases are a family of proteins found in methylotrophic or autotrophic bacteria. These quinoproteins use pyrroloquinoline quinone as their prosthetic group. There are three types of alcohol dehydrogenases: type I includes methanol dehydrogenase and ethanol dehydrogenase, type II includes soluble quinohaemoprotein with a C-terminal containing haem C, and type III includes quinoprotein alcohol dehydrogenase with a C-terminal cytochrome C domain [ 1 ]. These quinoproteins contain an 8-bladed beta-propeller motif, which is present in the N-terminal domain of quinoprotein alcohol dehydrogenase, ethanol dehydrogenase, and the heavy chain (alpha subunit) of methanol dehydrogenase ( 1.1.99.8 ) [ 2 , 3 , 4 ].

This entry represents quinoprotein alcohol dehydrogenases as well as some other proteins that share a similar structure, including WD repeat-containing protein and echinoderm microtubule-associated protein-like proteins.

1. Pyrroloquinoline quinone (PQQ) and quinoprotein enzymes. Antioxid. Redox Signal. 3, 757-74
2. Crystal structure of quinohemoprotein alcohol dehydrogenase from Comamonas testosteroni: structural basis for substrate oxidation and electron transfer. J. Biol. Chem. 277, 3727-32
3. The ethanol oxidation system and its regulation in Pseudomonas aeruginosa. Biochim. Biophys. Acta 1647, 98-102
4. The structure and mechanism of methanol dehydrogenase. Biochim. Biophys. Acta 1647, 18-23