Gene: AT5G08280

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT5G08280
  • Transcript Identifier AT5G08280.1
  • Gene Type Coding gene
  • Location Chr5 : 2663763-2665596 : negative

Gene Family Information

  • ID HOM05D004008
  • #Genes/#Species 175/98
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT5G08280.1
  • symbol HEMC
  • Alias RUG1,RUGOSA 1
  • uniprot Q43316

Descriptions

  • Description hydroxymethylbilane synthase
  • Computational description hydroxymethylbilane synthase (HEMC); FUNCTIONS IN: hydroxymethylbilane synthase activity; INVOLVED IN: chlorophyll biosynthetic process, defense response to bacterium, porphyrin biosynthetic process; LOCATED IN: apoplast, chloroplast, chloroplast stroma, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Porphobilinogen deaminase, dipyrromethane cofactor binding site (InterPro:IPR022419), Tetrapyrrole biosynthesis, hydroxymethylbilane synthase (InterPro:IPR000860), Porphobilinogen deaminase, N-terminal (InterPro:IPR022417), Porphobilinogen deaminase, C-terminal domain (InterPro:IPR022418); Has 7343 Blast hits to 7329 proteins in 2247 species: Archae - 198; Bacteria - 4150; Metazoa - 157; Fungi - 178; Plants - 78; Viruses - 0; Other Eukaryotes - 2582 (source: NCBI BLink).
  • Loading (ortholog descriptions from ath)...

Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0015995
TAS, IEA
Gene Ontologychlorophyll biosynthetic process1
GO:0033014
IEA
GOA Databasetetrapyrrole biosynthetic process
GO:0033014
IEA
InterProtetrapyrrole biosynthetic process
GO:0006779
IEA
GOA Databaseporphyrin-containing compound biosynthetic process
GO:0006779
TAS
Gene Ontologyporphyrin-containing compound biosynthetic process2
GO:0042742
IEP
GOA Databasedefense response to bacterium
GO:0006783
IBA
Gene Ontologyheme biosynthetic process3
GO:0006782
IEA
Gene Ontologyprotoporphyrinogen IX biosynthetic process
GO:1900865
IMP
Gene Ontologychloroplast RNA modification4
GO:0018160
IEA
Gene Ontologypeptidyl-pyrromethane cofactor linkage

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0004418
IEA
GOA Databasehydroxymethylbilane synthase activity
GO:0004418
IDA, IMP
IBA
Gene Ontologyhydroxymethylbilane synthase activity1 3 5
GO:0004418
IEA
InterProhydroxymethylbilane synthase activity
GO:0016740
IEA
GOA Databasetransferase activity
GO:0005515
IPI
Gene Ontologyprotein binding4

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0009536
IEA
GOA Databaseplastid
GO:0048046
IDA
GOA Databaseapoplast
GO:0048046
HDA
Gene Ontologyapoplast6
GO:0009941
IDA
GOA Databasechloroplast envelope
GO:0009941
HDA
Gene Ontologychloroplast envelope7
GO:0009570
IDA
GOA Databasechloroplast stroma
GO:0009570
HDA
Gene Ontologychloroplast stroma8
GO:0009507
IEA
GOA Databasechloroplast
GO:0009507
IDA, HDA
ISM
Gene Ontologychloroplast2 9
GO:0005737
IBA
Gene Ontologycytoplasm3
GO:0005886
HDA
Gene Ontologyplasma membrane10

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR022418 Porphobilinogen deaminase, C-terminal
IPR000860 Porphobilinogen deaminase
IPR022417 Porphobilinogen deaminase, N-terminal
IPR036803 Porphobilinogen deaminase, C-terminal domain superfamily
Mapman id Description
7.12.2.2 Coenzyme metabolism.tetrapyrrol biosynthesis.uroporphyrinogen III formation.porphobilinogen deaminase