Gene: AT4G17380

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT4G17380
  • Transcript Identifier AT4G17380.1
  • Gene Type Coding gene
  • Location Chr4 : 9708742-9714068 : positive

Gene Family Information

  • ID HOM05D005550
  • #Genes/#Species 138/97
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT4G17380.1
  • symbol MSH4
  • Alias ATMSH4,ARABIDOPSIS MUTS HOMOLOG 4
  • uniprot F4JP48

Descriptions

  • Description MUTS-like protein 4
  • Computational description MUTS-like protein 4 (MSH4); FUNCTIONS IN: damaged DNA binding, mismatched DNA binding, ATP binding; INVOLVED IN: mismatch repair, synapsis, meiotic prophase I; LOCATED IN: condensed nuclear chromosome; EXPRESSED IN: flower, sporocyte; EXPRESSED DURING: petal differentiation and expansion stage, IL.00 inflorescence just visible; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS, core (InterPro:IPR007696); BEST Arabidopsis thaliana protein match is: MUTS homolog 2 (TAIR:AT3G18524.1); Has 13303 Blast hits to 13154 proteins in 2712 species: Archae - 169; Bacteria - 9120; Metazoa - 661; Fungi - 837; Plants - 451; Viruses - 3; Other Eukaryotes - 2062 (source: NCBI BLink).
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000710
IBA
Gene Ontologymeiotic mismatch repair1
GO:0006298
IEA
Gene Ontologymismatch repair
GO:0006298
IEA
InterPromismatch repair
GO:0051321
IEA
GOA Databasemeiotic cell cycle
GO:0000712
IBA
Gene Ontologyresolution of meiotic recombination intermediates1
GO:0007129
IMP, IGI
Gene Ontologyhomologous chromosome pairing at meiosis2 3
GO:0045143
IMP
Gene Ontologyhomologous chromosome segregation2
GO:0010777
IMP
Gene Ontologymeiotic mismatch repair involved in reciprocal meiotic recombination2

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0030983
IEA
Gene Ontologymismatched DNA binding
GO:0030983
IEA
InterPromismatched DNA binding
GO:0005524
IEA
GOA DatabaseATP binding
GO:0005524
IEA
InterProATP binding
GO:0000166
IEA
GOA Databasenucleotide binding
GO:0003677
IEA
GOA DatabaseDNA binding
GO:0008094
IBA
Gene OntologyATPase, acting on DNA1

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0009506
IDA
GOA Databaseplasmodesma
GO:0009506
HDA
Gene Ontologyplasmodesma4
GO:0005634
IEA
GOA Databasenucleus
GO:0005634
ISM
Gene Ontologynucleus
GO:0000795
IBA
Gene Ontologysynaptonemal complex1
GO:0043073
IDA
Gene Ontologygerm cell nucleus2
GO:0000794
IDA
Gene Ontologycondensed nuclear chromosome2

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR007861 DNA mismatch repair protein MutS, clamp
IPR036187 DNA mismatch repair protein MutS, core domain superfamily
IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR045076 DNA mismatch repair MutS family
IPR036678 MutS, connector domain superfamily
IPR011184 DNA mismatch repair Msh2-type
IPR007696 DNA mismatch repair protein MutS, core
Mapman id Description
13.3.5.5.1.2.1 Cell cycle organisation.mitosis and meiosis.meiotic recombination.meiotic crossover.class I interference-sensitive crossover pathway.MSH4-MSH5 Holliday junction stabilizing heterodimer.component MSH4