Gene: AT4G09140

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT4G09140
  • Transcript Identifier AT4G09140.2
  • Gene Type Coding gene
  • Location Chr4 : 5817107-5820224 : negative

Gene Family Information

  • ID HOM05D005290
  • #Genes/#Species 143/98
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT4G09140.2
  • symbol MLH1
  • Alias ATMLH1,ARABIDOPSIS THALIANA MUTL-HOMOLOGUE 1
  • uniprot Q9ZRV4

Descriptions

  • Description MUTL-homologue 1
  • Computational description MUTL-homologue 1 (MLH1); FUNCTIONS IN: protein binding, bridging; INVOLVED IN: in 6 processes; LOCATED IN: nuclear chromatin; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Mlh1 (InterPro:IPR011186), DNA mismatch repair, conserved site (InterPro:IPR014762), ATPase-like, ATP-binding domain (InterPro:IPR003594), DNA mismatch repair protein, C-terminal (InterPro:IPR013507), DNA mismatch repair protein, N-terminal (InterPro:IPR014763), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), DNA mismatch repair protein (InterPro:IPR002099), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721); BEST Arabidopsis thaliana protein match is: DNA mismatch repair protein, putative (TAIR:AT4G02460.1); Has 6802 Blast hits to 6727 proteins in 2342 species: Archae - 68; Bacteria - 4480; Metazoa - 469; Fungi - 496; Plants - 114; Viruses - 0; Other Eukaryotes - 1175 (source: NCBI BLink).
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006298
ISS, IBA
IEA
Gene Ontologymismatch repair1 2
GO:0006298
IEA
InterPromismatch repair
GO:0006974
IEA
GOA Databasecellular response to DNA damage stimulus
GO:0006281
IEA
GOA DatabaseDNA repair
GO:0048316
IMP
Gene Ontologyseed development3
GO:0010154
IMP
Gene Ontologyfruit development3
GO:0009845
IMP
Gene Ontologyseed germination3
GO:0009555
IMP
Gene Ontologypollen development3
GO:0006312
IMP
Gene Ontologymitotic recombination3

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016887
IBA
Gene OntologyATP hydrolysis activity2
GO:0016887
IEA
InterProATP hydrolysis activity
GO:0030983
IEA
Gene Ontologymismatched DNA binding
GO:0030983
IEA
InterPromismatched DNA binding
GO:0005524
IEA
Gene OntologyATP binding
GO:0005524
IEA
InterProATP binding
GO:0030674
ISS
Gene Ontologyprotein-macromolecule adaptor activity1

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0000785
IDA
Gene Ontologychromatin4
GO:0032300
IBA
IEA
Gene Ontologymismatch repair complex2
GO:0032300
IEA
InterPromismatch repair complex
GO:0005634
IEA
GOA Databasenucleus
GO:0005634
ISM
Gene Ontologynucleus
GO:0032389
IBA
Gene OntologyMutLalpha complex2

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR013507 DNA mismatch repair protein, S5 domain 2-like
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
IPR036890 Histidine kinase/HSP90-like ATPase superfamily
IPR038973 DNA mismatch repair protein MutL/Mlh/Pms
IPR032189 DNA mismatch repair protein Mlh1, C-terminal
IPR020568 Ribosomal protein S5 domain 2-type fold
Mapman id Description
14.7.2.1 DNA damage response.mismatch repair (MMR).MLH1-PMS1 heterodimer.component MLH1