InterPro domain: IPR013507
General Information
- Identifier IPR013507
- Description DNA mismatch repair protein, S5 domain 2-like
- Number of genes 315
- Gene duplication stats Loading...
- Associated GO terms GO:0005524 GO:0006298 GO:0030983
Abstract
This domain is found in MutL and homologues and is characterized by a ribosomal protein S5 domain 2-like fold [ 1 ].
The dimeric MutL protein has a key function in communicating mismatch recognition by MutS to downstream repair processes. Mismatch repair contributes to the overall fidelity of DNA replication by targeting mispaired bases that arise through replication errors during homologous recombination and as a result of DNA damage. It involves the correction of mismatched base pairs that have been missed by the proofreading element of the DNA polymerase complex [ 2 ].
1. Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome. Acta Crystallogr F Struct Biol Commun 71, 981-5
2. DNA mismatch repair: molecular mechanisms and biological function. Annu. Rev. Microbiol. 57, 579-608