Gene: AT4G02070

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT4G02070
  • Transcript Identifier AT4G02070.1
  • Gene Type Coding gene
  • Location Chr4 : 906079-912930 : positive

Gene Family Information

  • ID HOM05D001061
  • #Genes/#Species 575/100
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT4G02070.1
  • symbol MSH6
  • Alias ATMSH6,ARABIDOPSIS THALIANA MUTS HOMOLOG 6
  • uniprot O04716

Descriptions

  • Description MUTS homolog 6
  • Computational description MUTS homolog 6 (MSH6); FUNCTIONS IN: damaged DNA binding; INVOLVED IN: mismatch repair; LOCATED IN: chloroplast; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Msh6 (InterPro:IPR017261), DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), Tudor domain (InterPro:IPR002999); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1); Has 29702 Blast hits to 21889 proteins in 2967 species: Archae - 234; Bacteria - 11721; Metazoa - 3243; Fungi - 2118; Plants - 3658; Viruses - 802; Other Eukaryotes - 7926 (source: NCBI BLink).
  • Loading (ortholog descriptions from ath)...

Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0043570
IBA
Gene Ontologymaintenance of DNA repeat elements1
GO:0006298
ISS, IBA
IEA
Gene Ontologymismatch repair1 2
GO:0006298
IEA
InterPromismatch repair
GO:0006974
IEA
GOA Databasecellular response to DNA damage stimulus
GO:0006281
IEA
GOA DatabaseDNA repair
GO:0006290
IMP
IBA
Gene Ontologypyrimidine dimer repair1 3
GO:0045910
IBA
Gene Ontologynegative regulation of DNA recombination1
GO:0000710
IBA
Gene Ontologymeiotic mismatch repair1
GO:0036297
IBA
Gene Ontologyinterstrand cross-link repair1

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005524
IEA
GOA DatabaseATP binding
GO:0005524
IEA
InterProATP binding
GO:0030983
IEA
GOA Databasemismatched DNA binding
GO:0030983
IBA
Gene Ontologymismatched DNA binding1
GO:0030983
IEA
InterPromismatched DNA binding
GO:0000166
IEA
GOA Databasenucleotide binding
GO:0003677
IEA
GOA DatabaseDNA binding
GO:0032405
IBA
Gene OntologyMutLalpha complex binding1
GO:0032143
IBA
Gene Ontologysingle thymine insertion binding1
GO:0032357
IBA
Gene Ontologyoxidized purine DNA binding1
GO:0008094
IBA
Gene OntologyATPase, acting on DNA1
GO:0000400
IBA
Gene Ontologyfour-way junction DNA binding1
GO:0005515
IPI
Gene Ontologyprotein binding2
GO:0003684
IDA
Gene Ontologydamaged DNA binding2

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005634
IEA
GOA Databasenucleus
GO:0005634
ISM
Gene Ontologynucleus
GO:0032300
IBA
Gene Ontologymismatch repair complex1
GO:0032301
IBA
Gene OntologyMutSalpha complex1

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR017261 DNA mismatch repair protein MutS/MSH
IPR045076 DNA mismatch repair MutS family
IPR036678 MutS, connector domain superfamily
IPR016151 DNA mismatch repair protein MutS, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR000432 DNA mismatch repair protein MutS, C-terminal
IPR007861 DNA mismatch repair protein MutS, clamp
IPR007696 DNA mismatch repair protein MutS, core
IPR007695 DNA mismatch repair protein MutS-like, N-terminal
IPR007860 DNA mismatch repair protein MutS, connector domain
IPR002999 Tudor domain
IPR036187 DNA mismatch repair protein MutS, core domain superfamily
Mapman id Description
14.7.1.3 DNA damage response.mismatch repair (MMR).MSH2-x mismatch repair heterodimer components.component MSH6