Gene: AT4G02060
General Information
Structural Information
- Species Arabidopsis thaliana
- Gene Identifier AT4G02060
- Transcript Identifier AT4G02060.2
- Gene Type Coding gene
- Location Chr4 : 901484-905297 : positive
Gene Family Information
- ID HOM05D000361
- #Genes/#Species 1321/100
- Phylogenetic origin
- ID ORTHO05D005006
- #Genes/#Species 166/100
- Phylogenetic origin
Gene Duplication Information
- Tandem Duplication Tandem duplicate
Labels
Identifiers
- tid AT4G02060.2
- symbol PRL
- Alias MCM7
- full_name PROLIFERA
- uniprot P43299
Descriptions
- Description Minichromosome maintenance (MCM2/3/5) family protein
- Computational description PROLIFERA (PRL); FUNCTIONS IN: protein binding, DNA-dependent ATPase activity, DNA binding, ATP binding; INVOLVED IN: sugar mediated signaling pathway, cell proliferation, DNA-dependent DNA replication initiation, DNA unwinding involved in replication; LOCATED IN: nuclear chromatin, nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 7 (InterPro:IPR008050); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1); Has 4609 Blast hits to 4442 proteins in 796 species: Archae - 407; Bacteria - 660; Metazoa - 1239; Fungi - 945; Plants - 433; Viruses - 2; Other Eukaryotes - 923 (source: NCBI BLink).
- Computational description PROLIFERA (PRL); CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), Nucleic acid-binding, OB-fold (InterPro:IPR012340), ATPase, AAA type, core (InterPro:IPR003593), DNA-dependent ATPase MCM (InterPro:IPR001208), DNA-dependent ATPase MCM, conserved site (InterPro:IPR018525), MCM protein 7 (InterPro:IPR008050); BEST Arabidopsis thaliana protein match is: minichromosome maintenance (MCM2/3/5) family protein (TAIR:AT5G44635.1).
- Loading (ortholog descriptions from ath)...
Functional Annotation
Biological Process
| GO term | Evidence(s) | Provider(s) | Description | Source(s) |
|---|---|---|---|---|
| GO:0006260 | IEA | GOA Database | DNA replication | |
| GO:0007049 | IEA | GOA Database | cell cycle | |
| GO:0006270 | IEA | GOA Database | DNA replication initiation | |
| GO:0006270 | IBA | Gene Ontology | DNA replication initiation | 1 |
| GO:0006270 | IEA | InterPro | DNA replication initiation | |
| GO:0032508 | IEA | GOA Database | DNA duplex unwinding | |
| GO:0032508 | IEA | InterPro | DNA duplex unwinding | |
| GO:0006267 | IBA | GOA Database | pre-replicative complex assembly involved in nuclear cell cycle DNA replication | |
| GO:0009790 | IMP | Gene Ontology | embryo development | 2 |
| GO:0010182 | TAS | Gene Ontology | sugar mediated signaling pathway | 3 |
| GO:0006268 | IBA TAS | Gene Ontology | DNA unwinding involved in DNA replication | 1 4 |
| GO:0009555 | IMP | Gene Ontology | pollen development | 2 |
| GO:0006271 | IBA | Gene Ontology | DNA strand elongation involved in DNA replication | 1 |
| GO:0000727 | IBA | Gene Ontology | double-strand break repair via break-induced replication | 1 |
Molecular Function
| GO term | Evidence(s) | Provider(s) | Description | Source(s) |
|---|---|---|---|---|
| GO:0003678 | IEA | GOA Database | DNA helicase activity | |
| GO:0003678 | IEA | InterPro | DNA helicase activity | |
| GO:0046872 | IEA | GOA Database | metal ion binding | |
| GO:0003677 | IEA | GOA Database | DNA binding | |
| GO:0003677 | IEA | InterPro | DNA binding | |
| GO:0000166 | IEA | GOA Database | nucleotide binding | |
| GO:0016787 | IEA | GOA Database | hydrolase activity | |
| GO:0004386 | IEA | GOA Database | helicase activity | |
| GO:0005524 | IEA | GOA Database | ATP binding | |
| GO:0005524 | IEA | InterPro | ATP binding | |
| GO:0005515 | IPI | Gene Ontology | protein binding | 5 |
| GO:0003697 | IBA | Gene Ontology | single-stranded DNA binding | 1 |
| GO:0017116 | IBA | Gene Ontology | single-stranded DNA helicase activity | 1 |
Cellular Component
| GO term | Evidence(s) | Provider(s) | Description | Source(s) |
|---|---|---|---|---|
| GO:0042555 | IEA | GOA Database | MCM complex | |
| GO:0042555 | IBA | Gene Ontology | MCM complex | 1 |
| GO:0042555 | IEA | InterPro | MCM complex | |
| GO:0005737 | IEA | GOA Database | cytoplasm | |
| GO:0005737 | IDA | Gene Ontology | cytoplasm | 4 |
| GO:0005634 | IDA ISM, IBA | Gene Ontology | nucleus | 1 6 |
| GO:0000347 | IDA | Gene Ontology | THO complex | 5 |
| GO:0000785 | IDA | Gene Ontology | chromatin | 4 |
| GO:0005829 | RCA | Gene Ontology | cytosol | 7 |
Color Legend
| Experimental Evidence |
| Computational Reviewed Evidence |
| Electronic Evidence |
| InterPro | Description |
|---|---|
| IPR027925 | MCM N-terminal domain |
| IPR031327 | Mini-chromosome maintenance protein |
| IPR033762 | MCM OB domain |
| IPR001208 | MCM domain |
| IPR012340 | Nucleic acid-binding, OB-fold |
| IPR008050 | DNA replication licensing factor Mcm7 |
| IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| IPR041562 | MCM, AAA-lid domain |
| Mapman id | Description |
|---|---|
| 13.2.1.2.6 | Cell cycle organisation.DNA replication.preinitiation.MCM replicative DNA helicase complex.component MCM7 |