Gene: AT2G17370

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT2G17370
  • Transcript Identifier AT2G17370.1
  • Gene Type Coding gene
  • Location Chr2 : 7550007-7551981 : positive

Gene Family Information

  • ID HOM05D000935
  • #Genes/#Species 645/97
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT2G17370.1
  • symbol HMG2
  • Alias HMGR2,3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 2
  • uniprot P43256

Descriptions

  • Description 3-hydroxy-3-methylglutaryl-CoA reductase 2
  • Computational description 3-hydroxy-3-methylglutaryl-CoA reductase 2 (HMG2); CONTAINS InterPro DOMAIN/s: Hydroxymethylglutaryl-CoA reductase, class I, catalytic (InterPro:IPR004554), Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding (InterPro:IPR009029), Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding (InterPro:IPR009023), Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic (InterPro:IPR002202); BEST Arabidopsis thaliana protein match is: hydroxy methylglutaryl CoA reductase 1 (TAIR:AT1G76490.1); Has 2106 Blast hits to 2105 proteins in 886 species: Archae - 203; Bacteria - 937; Metazoa - 224; Fungi - 225; Plants - 261; Viruses - 1; Other Eukaryotes - 255 (source: NCBI BLink).
  • Loading (ortholog descriptions from ath)...

Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0008299
IEA
GOA Databaseisoprenoid biosynthetic process
GO:0008299
IBA
TAS
Gene Ontologyisoprenoid biosynthetic process1 2
GO:0008299
IEA
InterProisoprenoid biosynthetic process
GO:0015936
IEA
Gene Ontologycoenzyme A metabolic process
GO:0015936
IEA
InterProcoenzyme A metabolic process
GO:0016126
IMP
IBA
Gene Ontologysterol biosynthetic process2 3
GO:0016104
IMP
Gene Ontologytriterpenoid biosynthetic process3

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016616
IEA
GOA Databaseoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0016616
IEA
InterProoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0005515
IEA
InterProprotein binding
GO:0004420
IEA
GOA Databasehydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0004420
IBA
Gene Ontologyhydroxymethylglutaryl-CoA reductase (NADPH) activity2
GO:0004420
IEA
InterProhydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0016491
IEA
GOA Databaseoxidoreductase activity

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005789
IEA
GOA Databaseendoplasmic reticulum membrane
GO:0005789
IBA
Gene Ontologyendoplasmic reticulum membrane2
GO:0005783
IEA
GOA Databaseendoplasmic reticulum
GO:0016020
IEA
GOA Databasemembrane
GO:0016021
IEA
GOA Databaseintegral component of membrane
GO:0005634
ISM
Gene Ontologynucleus
GO:0005778
IBA
Gene Ontologyperoxisomal membrane2
GO:0043231
IDA
Gene Ontologyintracellular membrane-bounded organelle4

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR023074 Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic domain superfamily
IPR002202 Hydroxymethylglutaryl-CoA reductase, class I/II
IPR004554 Hydroxymethylglutaryl-CoA reductase, eukaryotic/archaeal type
IPR009023 Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily
IPR009029 Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding domain superfamily
IPR023282 Hydroxymethylglutaryl-CoA reductase, N-terminal
Mapman id Description
9.1.1.3 Secondary metabolism.terpenoids.mevalonate pathway.3-hydroxy-3-methylglutaryl-CoA reductase