Gene: AT2G16370

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT2G16370
  • Transcript Identifier AT2G16370.2
  • Gene Type Coding gene
  • Location Chr2 : 7082500-7084333 : negative

Gene Family Information

  • ID HOM05D002765
  • #Genes/#Species 250/99
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT2G16370.2
  • symbol THY-1
  • uniprot Q05762

Descriptions

  • Description thymidylate synthase 1
  • Computational description thymidylate synthase 1 (THY-1); CONTAINS InterPro DOMAIN/s: Thymidylate synthase, active site (InterPro:IPR020940), Dihydrofolate reductase domain (InterPro:IPR001796), Dihydrofolate reductase conserved site (InterPro:IPR017925), Bifunctional dihydrofolate reductase/thymidylate synthase (InterPro:IPR012262), Thymidylate synthase (InterPro:IPR000398); BEST Arabidopsis thaliana protein match is: thymidylate synthase 2 (TAIR:AT4G34570.1); Has 13474 Blast hits to 13433 proteins in 2607 species: Archae - 76; Bacteria - 8708; Metazoa - 513; Fungi - 424; Plants - 92; Viruses - 253; Other Eukaryotes - 3408 (source: NCBI BLink).
  • Loading (ortholog descriptions from ath)...

Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0046654
IEA
Gene Ontologytetrahydrofolate biosynthetic process
GO:0046654
IEA
InterProtetrahydrofolate biosynthetic process
GO:0006730
IEA
GOA Databaseone-carbon metabolic process
GO:0006730
IEA
InterProone-carbon metabolic process
GO:0006231
IBA
IEA
Gene OntologydTMP biosynthetic process1
GO:0006231
IEA
InterProdTMP biosynthetic process
GO:0032259
IEA
GOA Databasemethylation
GO:0009165
IEA
GOA Databasenucleotide biosynthetic process
GO:0008152
IEA
GOA Databasemetabolic process
GO:0009257
ISS
Gene Ontology10-formyltetrahydrofolate biosynthetic process2

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0016741
IEA
GOA Databasetransferase activity, transferring one-carbon groups
GO:0016741
IEA
InterProtransferase activity, transferring one-carbon groups
GO:0004146
IDA
ISS, IBA
IEA
Gene Ontologydihydrofolate reductase activity1 2 3
GO:0004146
IEA
InterProdihydrofolate reductase activity
GO:0004799
ISS, IBA
IEA
Gene Ontologythymidylate synthase activity1 2
GO:0004799
IEA
InterProthymidylate synthase activity
GO:0008168
IEA
GOA Databasemethyltransferase activity
GO:0016491
IEA
GOA Databaseoxidoreductase activity
GO:0016740
IEA
GOA Databasetransferase activity
GO:0003824
IEA
GOA Databasecatalytic activity
GO:0005515
IPI
Gene Ontologyprotein binding4

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005829
IDA
GOA Databasecytosol
GO:0005829
IBA
Gene Ontologycytosol1
GO:0005739
IBA
Gene Ontologymitochondrion1
GO:0005737
IDA
ISM
Gene Ontologycytoplasm3

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain
IPR000398 Thymidylate synthase
IPR024072 Dihydrofolate reductase-like domain superfamily
IPR012262 Bifunctional dihydrofolate reductase/thymidylate synthase
IPR001796 Dihydrofolate reductase domain
IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily
IPR045097 Thymidylate synthase/dCMP hydroxymethylase
Mapman id Description
6.3.1.2 Nucleotide metabolism.deoxynucleotides.biosynthesis.thymidylate synthase
7.5.5 Coenzyme metabolism.tetrahydrofolate metabolism.dihydrofolate reductase