InterPro domain: IPR024072
General Information
- Identifier IPR024072
- Description Dihydrofolate reductase-like domain superfamily
- Number of genes 498
- Gene duplication stats Loading...
Abstract
Dihydrofolate reductase (DHFR) catalyses the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate, an essential step in de novo synthesis both of glycine and of purines and deoxythymidine phosphate (the precursors of DNA synthesis) [ 1 ], and important also in the conversion of deoxyuridine monophosphate to deoxythymidine monophosphate.
This superfamily represents a structural domain found in dihydrofolate reductases, as well as in riboflavin biosynthesis proteins (usually as a C-terminal domain) and related enzymes.
1. A gene for dihydrofolate reductase in a herpesvirus. Science 239, 1145-7
Species distribution
Gene table
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