Gene: AT1G50480

General Information

Structural Information

  • Species Arabidopsis thaliana
  • Gene Identifier AT1G50480
  • Transcript Identifier AT1G50480.1
  • Gene Type Coding gene
  • Location Chr1 : 18702064-18704687 : positive

Gene Family Information

  • ID HOM05D004629
  • #Genes/#Species 157/96
  • Phylogenetic origin

Gene Duplication Information

Labels

Identifiers

  • tid AT1G50480.1
  • symbol THFS
  • uniprot Q9SPK5

Descriptions

  • Description 10-formyltetrahydrofolate synthetase
  • Computational description 10-formyltetrahydrofolate synthetase (THFS); FUNCTIONS IN: formate-tetrahydrofolate ligase activity, copper ion binding, ATP binding; INVOLVED IN: response to cadmium ion, folic acid and derivative biosynthetic process; LOCATED IN: apoplast, chloroplast, plasma membrane; EXPRESSED IN: 6 plant structures; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Formate-tetrahydrofolate ligase, FTHFS, conserved site (InterPro:IPR020628), Formate-tetrahydrofolate ligase, FTHFS (InterPro:IPR000559); BEST Arabidopsis thaliana protein match is: P-loop containing nucleoside triphosphate hydrolases superfamily protein (TAIR:AT2G12280.1); Has 7211 Blast hits to 7172 proteins in 1581 species: Archae - 30; Bacteria - 3794; Metazoa - 307; Fungi - 186; Plants - 64; Viruses - 0; Other Eukaryotes - 2830 (source: NCBI BLink).
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Functional Annotation

Biological Process

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0006730
IEA
GOA Databaseone-carbon metabolic process
GO:0046686
IEP
GOA Databaseresponse to cadmium ion
GO:0035999
IEA
Gene Ontologytetrahydrofolate interconversion

Molecular Function

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005524
IEA
GOA DatabaseATP binding
GO:0005524
IEA
InterProATP binding
GO:0004329
IEA
Gene Ontologyformate-tetrahydrofolate ligase activity
GO:0004329
IEA
InterProformate-tetrahydrofolate ligase activity
GO:0000166
IEA
GOA Databasenucleotide binding
GO:0016874
IEA
GOA Databaseligase activity
GO:0005507
HDA
Gene Ontologycopper ion binding1

Cellular Component

GO termEvidence(s)Provider(s)DescriptionSource(s)
GO:0005886
IDA
GOA Databaseplasma membrane
GO:0005829
IDA
GOA Databasecytosol
GO:0005829
HDA
Gene Ontologycytosol2
GO:0048046
IDA
GOA Databaseapoplast
GO:0048046
HDA
Gene Ontologyapoplast3
GO:0009507
IDA
GOA Databasechloroplast
GO:0009507
HDA
Gene Ontologychloroplast4
GO:0005634
HDA
Gene Ontologynucleus5
GO:0005737
ISM
Gene Ontologycytoplasm

Color Legend

Experimental Evidence
Computational Reviewed Evidence
Electronic Evidence
GO Sources: Primary Orthology Homology
Show redundant parents:
InterPro Description
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR000559 Formate-tetrahydrofolate ligase, FTHFS
Mapman id Description
7.5.7.1 Coenzyme metabolism.tetrahydrofolate metabolism.tetrahydrofolate (THF) interconversions.10-formyl-THF synthetase