Module
- Number
- 64
- Regulatory Genes
- 6
- Module Genes
- 21
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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nhr-31 | C26B2.3 | WBGene00003625 | 329 | View | |
zbed-6 | F25H8.6 | WBGene00009133 | 232 |
zbed-6 encodes a protein that contains a BED-type zinc finger domain; loss of zbed-6 activity in large-scale RNAi screens indicates that zbed-6 is required for larval development.
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F58E6.1 | F58E6.1 | WBGene00010251 | 154 |
The F58E6.1 encodes a protein that may be involved in apoptosis.
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sem-4 | F15C11.1 | WBGene00004773 | 131 |
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
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ekl-4 | Y105E8A.17 | WBGene00013676 | 105 | View | |
unc-86 | C30A5.7 | WBGene00006818 | 105 |
unc-86 encodes a transcription factor with a POU-type homeodomain that is required for correct fate determination and differentiaion in diverse neuronal lineages, including those of egg-laying neurons, mechanosensory neurons, and chemosensory interneurons; UNC-86 is orthologous to human BRN-3; UNC-86 is required for tph-1 and cat-1 expression in specific serotonergic neurons, as well as for neurite outgrowth.
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CLR Predictions
18 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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abu-11 | T01D1.6 | WBGene00000034 |
abu-11 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-11 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-11 may help protect the organism from damage by improperly folded nascent protein.
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bus-19 | T07F10.4 | WBGene00011590 |
bus-19 encodes an ancient but unfamiliar transmembrane protein required for colonization by Microbacterium nematophilum and the tail-swelling response to M. nematophilum infection, as well as for cuticle integrity and traction during movement, normal alae and body shape, dauer formation, normally rapid growth, and larval viability; BUS-19 (along with Y71A12C.2) is orthologous to human TMEM41A, and paralogous to TAG-175/D2013.10 and human TMEM41B; both BUS-19 and TAG-175 are orthologous to plant and fungal proteins such as budding yeast Tvp38p, and bacterial proteins such as Geobacter metallireducens DedA; given its orthology with Tvp38p, BUS-19 may colocalize to late Golgi vesicles with the Tlg2p ortholog SYN-16 and with a variety of other protein ligands.
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dpy-8 | C31H2.2 | WBGene00001070 |
dpy-8 encodes a collagen with a nematode-specific N-terminal domain that is required for normal body morphology and (perhaps) for a normal embryonic cell division rate; dpy-8 interacts genetically with emb-5 and glp-1.
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F10D11.6 | F10D11.6 | WBGene00008652 | View | |
F20B10.3 | F20B10.3 | WBGene00008967 | View | |
F28D1.9 | F28D1.9 | WBGene00009218 | View | |
glf-1 | H04M03.4 | WBGene00019154 |
H04M03.4 encodes a UDP-galactopyranose mutase predicted to synthesize galactofuranose (Gal(f)) as a nucleotide sugar (UDP-Gal(f)); recombinant H04M03.4 has biochemical activity either in vivo (expressed in E. coli) or in vitro; orthologs of H04M03.4 are found in the urochordates Halocynthia and Ciona.
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grl-5 | Y47D7A.5 | WBGene00001714 |
grl-5 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
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lgc-21 | C33G3.3 | WBGene00007903 | View | |
mlt-9 | F09B12.1 | WBGene00008605 | View | |
nspb-12 | F09F7.8 | WBGene00017305 | View | |
phat-2 | C46H11.9 | WBGene00016733 | View | |
pqn-74 | W02A2.3 | WBGene00004156 |
pqn-74 encodes a protein with two chitin-binding peritrophin-A domains, separated by a glutamine/asparagine (Q/N)-rich ('prion') domain; like CEJ-1 and CPG-2, PQN-74 might participate in eggshell synthesis and early embryonic development, and PQN-74's peritrophin-A domains might enable mechanical cross-linking of chitin.
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R57.2 | R57.2 | WBGene00020083 | View | |
T25E4.1 | T25E4.1 | WBGene00020803 | View | |
T27A10.6 | T27A10.6 | WBGene00020846 | View | |
W04G3.2 | W04G3.2 | WBGene00012256 | View | |
wrt-1 | ZK1290.12 | WBGene00006947 | View | |
ZK154.1 | ZK154.1 | WBGene00022665 | View | |
ZK180.6 | ZK180.6 | WBGene00022680 | View | |
ZK662.2 | ZK662.2 | WBGene00014039 | View |