Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

bus-19  

Sequence Name

T07F10.4  

WB ID

WBGene00011590  

Description

bus-19 encodes an ancient but unfamiliar transmembrane protein required for colonization by Microbacterium nematophilum and the tail-swelling response to M. nematophilum infection, as well as for cuticle integrity and traction during movement, normal alae and body shape, dauer formation, normally rapid growth, and larval viability; BUS-19 (along with Y71A12C.2) is orthologous to human TMEM41A, and paralogous to TAG-175/D2013.10 and human TMEM41B; both BUS-19 and TAG-175 are orthologous to plant and fungal proteins such as budding yeast Tvp38p, and bacterial proteins such as Geobacter metallireducens DedA; given its orthology with Tvp38p, BUS-19 may colocalize to late Golgi vesicles with the Tlg2p ortholog SYN-16 and with a variety of other protein ligands.