Module
- Number
- 56
- Regulatory Genes
- 5
- Module Genes
- 20
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
2L52.1 | 2L52.1 | WBGene00007063 | 347 |
2L52.1 encodes a protein with sequence similarity to GLI-family zinc-finger transcription factors; deletion mutations in 2L52.1 are reported to be homozygous viable.
|
View |
fos-1 | F29G9.4 | WBGene00001345 | 262 |
fos-1 encodes two basic region-leucine zipper (bZip) transcription factors, FOS-1A and FOS-1B, that are the sole C. elegans orthologs of the fos bZip transcription factor family; during hermaphrodite development, FOS-1A activity is required cell autonomously in the gonadal anchor cell for basement-membrane removal and subsequent anchor cell invasion of the vulval epithelium; in addition, fos-1 activity is also required for proper vulval and uterine development, fertility, and oogenesis; in late-L3 larvae, a FOS-1A translational fusion protein is expressed at high levels in the anchor cell nucleus and at lower levels in uterine cells, while a FOS-1B reporter is expressed at low levels in the anchor cell, uterine, and vulval cells; transcriptional reporters additionally reveal that fos-1b is expressed in most cells of late L3 larvae; in affecting anchor cell invasion, FOS-1A appears to act by regulating the expression of three AC-expressed genes: cdh-3/cadherin, him-4/hemicentin, and zmp-1/matrix metalloproteinase, which likely function together to promote anchor cell invasion.
|
View |
Y60A9.3 | Y60A9.3 | WBGene00013370 | 150 | View | |
H20J04.3 | H20J04.3 | WBGene00019218 | 130 | View | |
egl-43 | R53.3 | WBGene00001207 | 104 |
egl-43 encodes a zinc finger protein that affects HSN cell migration and development of the phasmid neurons; expressed in the HSN and phasmid neurons.
|
View |
CLR Predictions
None
Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
---|---|---|---|---|
C44E4.7 | C44E4.7 | WBGene00016656 | View | |
C53A5.6 | C53A5.6 | WBGene00008266 | View | |
col-83 | F33A8.9 | WBGene00000658 | View | |
F39H12.1 | F39H12.1 | WBGene00018212 | View | |
H19M22.4 | H19M22.4 | WBGene00023084 | View | |
hex-3 | Y39A1C.4 | WBGene00012663 |
hex-3 encodes a beta-N-acetylhexosaminidase.
|
View |
M117.4 | M117.4 | WBGene00010920 | View | |
src-1 | Y92H12A.1 | WBGene00005077 | View | |
sre-37 | F15A4.3 | WBGene00008839 | View | |
T22B11.1 | T22B11.1 | WBGene00020675 | View | |
taf-2 | Y37E11B.4 | WBGene00006383 |
taf-2 encodes a member of the peptidase M1 family, a predicted aminopeptidase with similarity to human TBP-associated factor 2.
|
View |
unc-33 | Y37E11C.1 | WBGene00006769 |
unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages.
|
View |
W02G9.3 | W02G9.3 | WBGene00020953 | View | |
W04A8.6 | W04A8.6 | WBGene00012241 | View | |
Y111B2A.19 | Y111B2A.19 | WBGene00013739 | View | |
Y116A8C.9 | Y116A8C.9 | WBGene00013789 | View | |
Y38E10A.23 | Y38E10A.23 | WBGene00012601 | View | |
Y39E4B.7 | Y39E4B.7 | WBGene00012718 | View | |
Y40A1A.3 | Y40A1A.3 | WBGene00021485 | View | |
Y48C3A.12 | Y48C3A.12 | WBGene00012994 | View |