Transcription regulatory networks in Caenorhabditis elegans
Gene
- Public Gene Name
-
unc-33
- Sequence Name
- Y37E11C.1
- WB ID
- WBGene00006769
- Description
-
unc-33 encodes a conserved member of the CRMP/TOAD/Ulip/DRP family of proteins that includes mammalian CRMP-2 (Collapsin response mediator protein-2), which is essential for axon guidance and axonogenesis; in C. elegans, unc-33 activity is required for several biological processes including outgrowth and guidance of sensory, motor, and interneurons, sex myoblast migration, normal body movement and morphology, egg laying, and defecation; by homology to CRMP-2, UNC-33 is predicted to bind tubulin heterodimers and promote microtubule assembly, thereby regulating the extension and branching of cellular projections during neuronal polarization; UNC-33 is reportedly expressed exclusively in axonal processes from after early embryogenesis through larval and adult stages.
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