Module
- Number
- 55
- Regulatory Genes
- 3
- Module Genes
- 23
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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sem-4 | F15C11.1 | WBGene00004773 | 1044 |
sem-4 encodes a zinc-finger protein; sem-4 activity is required for proper development of cells in neuronal, mesodermal, and vulval cell lineages; SEM-4::GFP reporter fusions are widely expressed with fluorescence seen in a number of different cell types including neurons, hypodermis, vulval precursor cells, and tail blast cells such as B and F.
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dpl-1 | T23G7.1 | WBGene00001061 | 240 |
dpl-1 encodes the C. elegans ortholog of mammalian DP, the E2F-heterodimerization partner; dpl-1 is a class B synMuv gene whose activity is required for oogenesis as well as embryonic asymmetry and vulval development; in addition, dpl-1 acts with a subset of class B synMuv genes and the MCD-1 zinc-finger protein to promote the killing process during programmed cell death; DPL-1 is a nuclear protein that is widely expressed throughout development in both somatic and germ cell lineages.
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ceh-33 | C10G8.7 | WBGene00000454 | 123 |
ceh-33 encodes a Six/sine oculis class homeodomain transcription factor; preliminary RNAi experiments suggest that CEH-33 activity may be required for gonad development; a ceh-33::gfp reporter shows very weak pharyngeal expression in late embryos and early larvae.
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CLR Predictions
70 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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aat-5 | C55C2.5 | WBGene00000006 |
aat-5 encodes a predicted amino acid transporter catalytic subunit; unlike catalytic subunits in other organisms, however, AAT-5 does not contain the highly conserved cysteine residue known to facilitate covalent interaction with a glycoprotein subunit, suggesting that AAT-5 does not require this residue for heterodimer formation or alternatively, does not require the glycoprotein subunit for function.
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C09D4.1 | C09D4.1 | WBGene00015632 | View | |
cal-4 | T07G12.1 | WBGene00000288 |
cal-4 encodes one of five predicted C. elegans calcium-binding calmodulin homologs (the others being CAL-1, CAL-2, CAL-3 and CMD-1); as loss of cal-4 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of CAL-4 in C. elegans development and/or behavior is not yet known.
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DH11.4 | DH11.4 | WBGene00008437 | View | |
eff-1 | C26D10.5 | WBGene00001159 |
eff-1 encodes novel, nematode-specific type I transmembrane and secreted glycoproteins; during development, EFF-1 functions as a fusogen required, in both fusion partners, for the initiation and expansion of membrane mergers that characterize cell fusions; eff-1(hy21) mutants are viable, but have severe body morphology defects associated with cell fusion failure; eff-1::GFP reporter fusions are expressed in the epidermis, pharynx, and uterus, as well as in some neurons; when expressed in tissue culture cells, the EFF-1A and EFF-1B isoforms are detected on the plasma membrane, while the EFF-1C isoform is found to be partially secreted.
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F08A10.1 | F08A10.1 | WBGene00008570 | View | |
F10F2.4 | F10F2.4 | WBGene00008656 | View | |
F31E3.2 | F31E3.2 | WBGene00017950 | View | |
F38B6.6 | F38B6.6 | WBGene00018175 | View | |
F54C9.11 | F54C9.11 | WBGene00010045 | View | |
glr-5 | ZC196.7 | WBGene00001616 |
glr-5 encodes a kainate (non-NMDA)-type ionotropic glutamate receptor subunit; GLR-5 activity is required for normal brood sizes, especially at high temperatures; GLR-5 is expressed in neurons.
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inx-1 | C16E9.4 | WBGene00002123 |
inx-1 encodes a predicted member of the innexin family; expressed in 4-6 anterior neurons.
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jnk-1 | B0478.1 | WBGene00002178 |
jnk-1 encodes a serine/threonine kinase that is the sole C. elegans member of the c-Jun N-terminal kinase (JNK) subgroup of mitogen-activated protein (MAP) kinases; JNK-1 exhibits kinase activity in vitro that is dependent upon activation by the JKK-1 MAPKK; a JNK-1::GFP translational fusion protein is expressed in nearly all neuronal cell bodies and processes, including the nerve ring, head and tail ganglions, and the dorsal and ventral nerve cords, at all stages of development.
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ncx-4 | F35C12.2 | WBGene00003569 |
ncx-4 encodes a putative 4Na[+]/1Ca[2+],1K[+] exchanger, orthologous to human SLC24A1-5 and paralogous to NCX-5; NCX-4 is predicted to export free cytoplasmic Ca[2+] with low affinity but high capacity, being complemented by low-capacity/high-affinity Ca[2+] ATPase pumps such as MCA-1/-3; NCX-4 has tandem Calx-alpha domains predicted to carry out ion transport; NCX-4 has no obvious function in mass RNAi assays.
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nhr-120 | C25B8.6 | WBGene00003710 | View | |
pdl-1 | C27H5.1 | WBGene00003966 | View | |
slo-1 | Y51A2D.19 | WBGene00004830 |
slo-1 mutants have wild-type levels of motor activity, but have less smooth movement and tend to stop and reverse direction.
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sul-2 | D1014.1 | WBGene00006309 |
sul-2 is orthologous to the human gene ARYLSULFATASE A (ARSA; OMIM:250100), which when mutated leads to metachromatic leukodystrophy.
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T22D1.12 | T22D1.12 | WBGene00020689 | View | |
unc-41 | C27H6.1 | WBGene00006777 |
unc-41 encodes an ortholog of Drosophila STONED A (STNA) required for normal locomotion; a beta-strand in the mu-adaptin-like domain of UNC-41 binds the C2A domain of SNT-1, and this binding is required for SNT-1 endocytosis, punctate localization of UNC-41 in neurons, and transgenic rescue of unc-41(e268) animals; UNC-41 is also required for normal secretion of EGL-17 from P6.p cells, and for embryonic viability; UNC-41 is expressed in the larval and adult nervous system; UNC-41, like other stonins, is an adaptin, and by orthology with stonins is predicted to be a protein adaptor that helps sort SNT-1 endocytotically.
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Y102A11A.2 | Y102A11A.2 | WBGene00022412 | View | |
Y57A10B.1 | Y57A10B.1 | WBGene00013273 | View | |
Y72A10A.1 | Y72A10A.1 | WBGene00022202 | View |