Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

eff-1  

Sequence Name

C26D10.5  

WB ID

WBGene00001159  

Description

eff-1 encodes novel, nematode-specific type I transmembrane and secreted glycoproteins; during development, EFF-1 functions as a fusogen required, in both fusion partners, for the initiation and expansion of membrane mergers that characterize cell fusions; eff-1(hy21) mutants are viable, but have severe body morphology defects associated with cell fusion failure; eff-1::GFP reporter fusions are expressed in the epidermis, pharynx, and uterus, as well as in some neurons; when expressed in tissue culture cells, the EFF-1A and EFF-1B isoforms are detected on the plasma membrane, while the EFF-1C isoform is found to be partially secreted.