Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

tbc-11  

Sequence Name

F35H12.2  

WB ID

WBGene00018075  

Description

F35H12.2 encodes, by alternative splicing, two isoforms of a putative Rab GTPase activator containing a TBC domain; F35H12.2 is orthologous to human RABGAP1 and RABGAP1L (OMIM:609238), and to budding yeast GYP5; F35H12.2 is paralogous to human TBC1D1 (OMIM:609850; variant in obesity) and TBC1D4/AS160; F35H12.2 is expressed very widely (in both larval and adult digestive, reproductive, and nervous systems, along with larval renal gland cells and distal tip cell); despite its wide expression and evolutionary conservation, F35H12.2 has no obvious function in either mass or targeted RNAi assays.