Module
- Number
- 51
- Regulatory Genes
- 5
- Module Genes
- 25
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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nhr-15 | F33E11.1 | WBGene00003614 | 630 |
nhr-15 is predicted to encode a member of the nuclear hormone receptor family.
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zim-1 | T07G12.6 | WBGene00011597 | 452 |
zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
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Y82E9BR.17 | Y82E9BR.17 | WBGene00022349 | 202 | View | |
nhr-172 | C54F6.9 | WBGene00016927 | 167 | View | |
pdhk-2 | ZK370.5 | WBGene00022719 | 152 | View |
CLR Predictions
12 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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app-1 | W03G9.4 | WBGene00000155 | View | |
C05C10.3 | C05C10.3 | WBGene00007330 |
C05C10.3 is orthologous to the human gene 3-OXOACID COA TRANSFERASE (also called succinyl-CoA:3-ketoacid CoA transferase; OXCT; OMIM:245050), which when mutated leads to episodic ketoacidosis.
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C06A6.4 | C06A6.4 | WBGene00015509 | View | |
C17H12.13 | C17H12.13 | WBGene00015938 | View | |
C32E8.3 | C32E8.3 | WBGene00016321 | View | |
C50B8.1 | C50B8.1 | WBGene00008224 | View | |
E01G4.3 | E01G4.3 | WBGene00008446 | View | |
E04D5.1 | E04D5.1 | WBGene00008480 | View | |
F09F7.4 | F09F7.4 | WBGene00017301 | View | |
F14B4.2 | F14B4.2 | WBGene00008780 | View | |
F23C8.5 | F23C8.5 | WBGene00017734 |
The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410).
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F25B5.3 | F25B5.3 | WBGene00017775 |
F25B5.3 is orthologous to the human gene NUCLEOTIDASE, 5-PRIME, CYTOSOLIC III (NT5C3; OMIM:606224), which when mutated leads to hemolytic anemia due to UMPH1 deficiency
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K10C3.2 | K10C3.2 | WBGene00010730 | View | |
lin-24 | B0001.1 | WBGene00003010 |
lin-24 encodes a protein containing a domain found in bacterial toxins such as the Bacillus sphaericus Mtx3 mosquitocidal toxin; lin-24 was originally identified in screens for mutations that result in altered vulval cell lineages and morphological examination of animals carrying a gain-of-function lin-24 mutation indicates that some of the Pn.p cells that normally make up the vulva undergo inappropriate cytotoxic cell death while others adopt inappropriate cell fates; the cytotoxic cell death seen in lin-24 mutant animals is dependent upon lin-33 and a number of programmed cell death genes, including the ced-2, ced-5, and ced-12 cell corpse engulfment genes.
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mbf-1 | H21P03.1 | WBGene00003148 | View | |
mdt-28 | W01A8.1 | WBGene00007024 | View | |
pqn-52 | M01E11.4 | WBGene00019713 |
pqn-52 encodes, by alternative splicing, three proteins with glutamine/asparagine (Q/N)-rich ('prion') domains; at least one of these isoforms bound KLC-2 in a mass yeast two-hybrid screen; PQN-52 proteins are predicted to be secreted, and have no obvious homologs outside of the nematodes (e.g., Brugia malayi 14952.m01392).
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R03D7.1 | R03D7.1 | WBGene00010988 |
R03D7.1 is orthologous to the human gene METHIONINE SYNTHASE (MTR; OMIM:156570), which when mutated leads to disease.
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rab-10 | T23H2.5 | WBGene00004273 |
rab-10 encodes a Rab-like GTPase that is a member of the Ras superfamily of small GTPases; rab-10 activity is required, upstream of rme-1, for basolateral endocytic recycling in the intestine, but not in oocytes or coelomocytes; a RAB-10::GFP fusion protein is widely expressed and in the intestine, localizes to endosomes and the Golgi.
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rpn-2 | C23G10.4 | WBGene00004459 |
rpn-2 encodes a non-ATPase subunit of the 26S proteasome's 19S regulatory paritcle (RP) base subcomplex; RPN-2 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding and recognition of protein substrates and/or recycling of ubiquitin moieties during protein degradation; RPN-2 is expressed sporadically at all stages of development in the pharynx, intestine, body wall muscle, somatic gonad, neurons, and hypodermis.
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T24H10.4 | T24H10.4 | WBGene00012002 | View | |
W01A11.1 | W01A11.1 | WBGene00020909 | View | |
wdr-23 | D2030.9 | WBGene00008419 | View | |
Y11D7A.10 | Y11D7A.10 | WBGene00012434 | View | |
ZK1320.9 | ZK1320.9 | WBGene00014258 | View |