Module
- Number
- 48
- Regulatory Genes
- 5
- Module Genes
- 21
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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H02I12.5 | H02I12.5 | WBGene00010353 | 660 | View | |
gla-3 | T02E1.3 | WBGene00011376 | 556 |
gla-3 encodes a TIS11-like protein with two CCCH-like zinc-finger domains that inhibits apoptosis in the germline, and weakly inhibits RAS signalling in vulval development along with RAS-induced muscle protein degradation; GLA-3 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; gla-3 is expressed in the germline of L4 larvae and adults, and interacts with mpk-1 both genetically and physically; gla-3 requires core apoptotic proteins (CED-3 and CED-4) for its excess apoptotic mutant phenotype, but not others (CEP-1, CLK-2, or HUS-1) required for DNA damage-induced apoptosis; gla-3 mutants have increased germline apoptosis and reduced brood size due to defective pachytene exit from meiosis I, and also show weak enhancment of the multivulva phenotype of let-60(gf) or lip-1(zh15) mutations; gla-3 mutants have temperature-sensitive progressive muscle dystrophy, consistent with hyperactivation of the RAS/MAPK pathway in muscle cells; gla-3(RNAi) hermaphrodites display elevated levels of physiological germline apoptosis, independent of CEP-1.
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zim-1 | T07G12.6 | WBGene00011597 | 222 |
zim-1 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-2/-3, and C02F5.12; ZIM-1 specifically required for homolog pairing, synapsis, and segregation of chromosomes II and III during meiosis; zim-1(tm1813) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes II and III; ZIM-1 associates with the left ends of chromosomes II and III, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-1 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-1 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-1 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
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cey-2 | F46F11.2 | WBGene00000473 | 124 |
cey-2 encodes a cold-shock/Y-box domain-containing protein; by homology, CEY-2 is predicted to function as either an RNA-binding protein involved in translation or RNA processing, or a DNA-binding protein involved in transcriptional regulation; cey-2 mRNA is expressed maternally in the early embryo, in a pattern characteristic of class II maternal RNAs, which are initially detected throughout the embryo but restricted to the P, or germline, lineage as cell division progresses; CEY-2 associates with CGH-1 and CEY-3/4 in cytoplasmic particles of the gonad and early embryo; as loss of cey-2 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of cey-2 in C. elegans development and/or behavior is not yet known.
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W02D9.3 | W02D9.3 | WBGene00012209 | 109 | View |
CLR Predictions
59 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0432.8 | B0432.8 | WBGene00015189 | View | |
C09H10.10 | C09H10.10 | WBGene00007504 | View | |
C14B1.7 | C14B1.7 | WBGene00007578 | View | |
F22G12.4 | F22G12.4 | WBGene00009064 | View | |
F39H2.5 | F39H2.5 | WBGene00009564 | View | |
F43D2.2 | F43D2.2 | WBGene00009651 | View | |
F43G6.3 | F43G6.3 | WBGene00009656 | View | |
F46F11.10 | F46F11.10 | WBGene00018513 | View | |
lin-41 | C12C8.3 | WBGene00003026 |
The lin-41 gene encodes a novel RBCC (Ring finger-B box-Coiled coil) protein that is a member of the NHL (NCL-1, HT2A, and LIN-41) family of proteins and is required for the proper temporal control of specific postembryonic cell fates; lin-41 translation is negatively regulated during L4 and adult stages by let-7, a small temporally regulated RNA (stRNA) that is complementary to two sites in the lin-41 3'UTR; LIN-41 is a widely expressed cytoplasmic protein and negatively regulates post-transcriptional expression of LIN-29, a transcription factor required for adult cell fates.
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M04B2.2 | M04B2.2 | WBGene00010846 | View | |
mcd-1 | Y51H1A.6 | WBGene00013096 |
mcd-1 encodes a highly acidic C2H2-type zinc-finger protein that, in conjunction with LIN-35/Rb, DPL-1/DP, EFL-1/E2F, LIN-37/Mip40, and LIN-52, promotes the developmentally programmed progression of cells through full apoptosis; MCD-1 can promote ectopic apoptosis in cells normally fated to live, and is thus active in such cells; MCD-1 is not required for CED-3-independent cell death, does not regulate CED-9, and probably does not transcriptionally regulate egl-1; MCD-1 and its partners do not act together with CED-1 or CED-8, and their function in cell death is distinct from the LET-60/RAS or SynMuv pathways; however, MCD-1 is redundantly required with some class B/C synMuv proteins for viability (LIN-9, LIN-35/Rb, or LIN-37/Mip40) and normally rapid growth (DPL-1/DP, LIN-13, LIN-53, LIN-54, or MYS-1); in mcd-1(n4005) animals, cells that would normally undergo apoptosis can instead pass through an episode of pre-apoptotic condensation, after which they sometimes revert to normal shape, survive, and differentiate; MCD-1 contains an N-terminal low-complexity region and a single central zinc-finger, but no other recognizable protein domains; MCD-1 is paralogous to Y48E1B.7, but has no obvious non-nematode orthologs.
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pup-2 | K10D2.2 | WBGene00019628 |
pup-2 encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to CID-1; like its paralog CID-1, PUP-2 is required for normally rapid growth and normally short lifespan; pup-2(RNAi) animals are slow-growing and abnormally long-lived; PUP-2 is paralogous to the GLD-2 family of poly(A) polymerases.
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R148.4 | R148.4 | WBGene00020103 | View | |
rib-1 | F12F6.3 | WBGene00004360 |
The rib-1 gene encodes an ortholog of human EXT1, which when mutated leads to hereditary multiple exostoses, type I (OMIM:133700).
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set-24 | Y43F11A.5 | WBGene00012845 |
set-24 encodes a protein with an N-terminal SET domain, followed by two SPK domains; SET-24's domain organization resembles that of SET-5, but SET-24 has no known non-nematode orthologs or C. elegans paralogs; neither set-24(n4909) nor set-24(RNAi) have any obvious phenotypes.
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T23H2.3 | T23H2.3 | WBGene00020742 | View | |
Y47D7A.14 | Y47D7A.14 | WBGene00021626 | View | |
Y53C10A.1 | Y53C10A.1 | WBGene00014915 | View | |
Y54G2A.19 | Y54G2A.19 | WBGene00021884 | View | |
Y69A2AR.32 | Y69A2AR.32 | WBGene00022101 | View | |
ZK1236.1 | ZK1236.1 | WBGene00022862 | View |