Module
- Number
- 47
- Regulatory Genes
- 4
- Module Genes
- 25
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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rab-1 | C39F7.4 | WBGene00004266 | 395 |
rab-1 encodes an ortholog of the small Ras-like GTPase Rab1; by homology, RAB-1 is predicted to play a role in intracellular vesicle trafficking, and consistent with this broad role, large-scale RNAi screens indicate that rab-1 activity is required for fertility, movement, and survival; in yeast two-hybrid assays, RAB-1 interacts with TIR-1, a C. elegans SARM ortholog that is required for innate immunity; RNAi studies suggest that RAB-1 and TIR-1 likely function in a pathway that controls expression of antimicrobial peptides such as NLP-29 and NLP-31; rab-1 also appears to play a role in regulating polyglutamine protein aggregation, as rab-1(RNAi) animals show premature accumulation of protein aggregates; in situ hybridization studies indicate that rab-1 is broadly expressed, with elevated levels apparent in the germline.
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nhr-219 | T19A5.5 | WBGene00020555 | 212 | View | |
srg-44 | F31E9.2 | WBGene00005201 | 157 | View | |
lsy-2 | F49H12.1 | WBGene00003087 | 135 |
lsy-2 encodes a novel C2H2 zinc-finger transcription factor that is most closely related to other nematode zinc-finger proteins; during development, lsy-2 is required for the left-right asymmetry of the ASE neurons; specifically, lsy-2 is required in ASEL for regulating the expression of the lsy-6 miRNA that controls the asymmetric expression of guanylyl cyclase chemoreceptors; a LSY-2::GFP reporter fusion is expressed ubiquitously from the 50-cell stage of embryogenesis through adulthood with expression seen in both ASEL and ASER; expression is localized to moving nuclear punctae.
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CLR Predictions
2 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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acs-16 | F37C12.7 | WBGene00018152 | View | |
C16A3.10 | C16A3.10 | WBGene00015814 |
The C16A3.10 gene encodes a homolog of the human gene OAT (OMIM:258870), which when mutated leads to ornithinemia and gyrate atrophy.
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C28H8.3 | C28H8.3 | WBGene00016194 | View | |
C32D5.8 | C32D5.8 | WBGene00016316 | View | |
C37C3.2 | C37C3.2 | WBGene00016496 | View | |
cas-1 | F41G4.2 | WBGene00000294 |
cas-1 encodes the C. elegans homologue of the adenylyl cyclase-associated protein 1 (CAP1); as loss of cas-1 activity via large-scale RNAi screens results in no obvious defects, the precise role of cas-1 in C. elegans development and/or behavior is not yet known.
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cct-7 | T10B5.5 | WBGene00020391 |
cct-7 encodes a putative eta subunit of the eukaryotic cytosolic ('T complex') chaperonin, orthologous to human CCT7 (OMIM:605140); CCT-7 is expressed in most, if not all, tissues; in mass RNAi assays, CCT-7 is required for normal transgene repression and subcellular localization, embryonic and larval viability, fertility, vulval development, and normal locomotion.
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dnj-13 | F54D5.8 | WBGene00001031 |
This gene encodes a protein containing a DnaJ ('J') domain.
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E02A10.1 | E02A10.1 | WBGene00008452 | View | |
ers-2 | ZC434.5 | WBGene00001337 |
ers-2 encodes a predicted mitochondrial glutamyl-tRNA synthetase (GluRS), a class I aminoacyl-tRNA synthetase that catalyzes the attachment of glutamate to its cognate tRNA and is thus required for protein biosynthesis; ERS-2 contains, at its C-terminus, six tandemly repeated WHEP-TRS domains that have been predicted to function as general RNA-binding domains that may act as cis tRNA-binding cofactors.
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F25B4.1 | F25B4.1 | WBGene00017765 |
F25B4.1 is orthologous to the human gene GLYCINE CLEAVAGE SYSTEM T-PROTEIN (AMT; OMIM:238310), which when mutated leads to glycine encephalopathy.
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F32A11.1 | F32A11.1 | WBGene00009307 | View | |
F38B2.4 | F38B2.4 | WBGene00009531 |
F38B2.4 is orthologous to the human gene ADENYLATE KINASE 1 (AK1; OMIM:103000), which when mutated leads to hemolytic anemia.
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F44E7.4 | F44E7.4 | WBGene00018426 | View | |
F45E12.5 | F45E12.5 | WBGene00018475 | View | |
hum-2 | F36D4.3 | WBGene00002036 |
hum-2 is orthologous to the human gene MYOSIN HEAVY CHAIN 12 (MYO5A; OMIM:160777), which when mutated leads to disease.
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rab-5 | F26H9.6 | WBGene00004268 |
rab-5 encodes the C. elegans Rab5 GTPase ortholog; RAB-5 activity is required for receptor-mediated yolk endocytosis and thus, for embryonic development; rab-5 mutations also affect localization of P granules and of PAR-2, as well as the cytoplasmic appearance of cells in the early embryo and larval development.
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T12D8.8 | T12D8.8 | WBGene00011735 | View | |
T28B11.1 | T28B11.1 | WBGene00012117 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
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tpi-1 | Y17G7B.7 | WBGene00006601 |
tpi-1 encodes a putative triosephosphate isomerase orthologous to human TPI1 (OMIM:190450, mutated in TPI deficiency) and Drosophila WASTED AWAY; loss of tpi-1 activity via RNAi results in increased resistance to exogenous oxidants and shortening of natural adult lifespan, both presumably due to alterations in the redox state of cells.
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unc-108 | F53F10.4 | WBGene00006833 |
unc-108 encodes a small GTPase homologous to the Rab GTPases that function in endocytosis, membrane fusion, and vesicular trafficking events; unc-108 function is required in neurons for normal locomotion; unc-108 also functions in the removal of apoptotic cells, specifically it functions in engulfing cells for the recruitment and fusion of the lysosome to the phagosome; unc-108 is expressed in neurons and in engulfing cells.
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vha-19 | Y55H10A.1 | WBGene00021952 |
vha-19 encodes an ortholog of subunit Ac45 of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-19 is a predicted V-ATPase transmembrane rotor component; Ac45 is a nonhomologous replacement for subunit c', which is found in fungi but not in animals; conversely, orthologs of Ac45 are only found in animals; VHA-19 is predicted to help carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export.
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Y71F9AL.17 | Y71F9AL.17 | WBGene00022119 |
Y71F9AL.17 encodes an alpha subunit of the coatomer (COPI) complex; in mass RNAi assays, Y71F9AL.17 is required for embryonic viability, fertility, normal locomotion, and normally rapid growth.
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Y71F9AL.9 | Y71F9AL.9 | WBGene00022114 | View | |
ZK858.6 | ZK858.6 | WBGene00014119 | View |