Module
- Number
- 273
- Regulatory Genes
- 3
- Module Genes
- 4
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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D2030.7 | D2030.7 | WBGene00008417 | 608 | View | |
hmg-3 | C32F10.5 | WBGene00001973 | 354 | View | |
mex-6 | AH6.5 | WBGene00003231 | 210 |
mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins.
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CLR Predictions
18 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C50E3.13 | C50E3.13 | WBGene00016824 | View | |
F14H3.4 | F14H3.4 | WBGene00008823 | View | |
him-14 | ZK1127.11 | WBGene00001872 |
him-14 encodes a germline-specific member of the MutS family of DNA mismatch repair (MMR) proteins that is orthologous to human MSH4 and Saccharomyces cerevisiae Msh4p; during the pachytene stage of meiosis, HIM-14 activity is required for promoting crossing over between homologous chromosomes and thus, for chiasmata formation and proper chromosome segregation; in contrast, HIM-14 activity does not appear to be required for mismatch repair, nor for chromosome pairing or synapsis; him-14 mRNA expression is detected exclusively in the germline.
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klp-10 | C33H5.4 | WBGene00002221 |
klp-10 encodes a predicted kinesin motor protein that while similar to the Xenopus and human klp2 kinesins, lacks the switch I motif critical for interaction with ATP; although RNAi experiments purportedly targeting klp-10 result in meiotic defects and embryonic lethality, loss of klp-10 activity via a deletion allele results in no obvious abnormalities, suggesting that the reported RNAi phenotypes are due to targeting of the highly similar klp-18 gene; klp-10 expression levels appear to be below the level of detection of RT-PCR, Northern, and Western analyses.
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