Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

klp-10  

Sequence Name

C33H5.4  

WB ID

WBGene00002221  

Description

klp-10 encodes a predicted kinesin motor protein that while similar to the Xenopus and human klp2 kinesins, lacks the switch I motif critical for interaction with ATP; although RNAi experiments purportedly targeting klp-10 result in meiotic defects and embryonic lethality, loss of klp-10 activity via a deletion allele results in no obvious abnormalities, suggesting that the reported RNAi phenotypes are due to targeting of the highly similar klp-18 gene; klp-10 expression levels appear to be below the level of detection of RT-PCR, Northern, and Western analyses.