Module
- Number
- 21
- Regulatory Genes
- 3
- Module Genes
- 47
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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D2030.7 | D2030.7 | WBGene00008417 | 679 | View | |
mex-6 | AH6.5 | WBGene00003231 | 630 |
mex-6 encodes a CCCH zinc-finger protein highly similar to MEX-5 that functions with MEX-5 to affect embryonic viability, establish soma germline asymmetry in embryos and establish PIE-1, MEX-1, and POS-1 asymmetry in embryos, and also affects formation of intestinal cells; MEX-6 and MEX-5 may act downstream of the PAR proteins.
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hmg-3 | C32F10.5 | WBGene00001973 | 214 | View |
CLR Predictions
181 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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B0261.7 | B0261.7 | WBGene00015095 | View | |
B0336.5 | B0336.5 | WBGene00015145 | View | |
bath-41 | F37A4.9 | WBGene00018137 |
The F37A4.9 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
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C14B1.9 | C14B1.9 | WBGene00007580 | View | |
C27B7.5 | C27B7.5 | WBGene00007762 | View | |
C48B4.11 | C48B4.11 | WBGene00008174 | View | |
cdc-25.1 | K06A5.7 | WBGene00000386 |
cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
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cdd-2 | F49E8.4 | WBGene00000392 |
A functional cytidine deaminase that affects morphology of embryos; it is expressed at all life cycle stages.
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cpar-1 | F54C8.2 | WBGene00010036 |
cpar-1 encodes one of two C. elegans proteins homologous to the inner kinetochore histone H3 variant CENP-A (the other is encoded by hcp-3); loss of cpar-1 and hcp-3 activity via RNAi results in mitotic chromosome segregation defects, but no significant defects in meiotic chromosome segregation; when expressed in the germline using the pie-1 promoter, a CPAR-1::GFP fusion protein localizes to meiotic chromosomes during late prophase/prometaphase of meiosis I, but is not seen on chromosomes during meiosis II.
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D2005.4 | D2005.4 | WBGene00008399 | View | |
dhs-11 | Y39A1A.11 | WBGene00000974 |
dhs-11 encodes a short-chain dehydrogenase predicted to be mitochondrial.
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F29G9.2 | F29G9.2 | WBGene00017931 | View | |
F30F8.1 | F30F8.1 | WBGene00009270 | View | |
F46F11.8 | F46F11.8 | WBGene00018511 | View | |
F54D5.14 | F54D5.14 | WBGene00010056 | View | |
fbxa-101 | F08A8.7 | WBGene00008569 | View | |
fbxa-210 | Y37H2A.5 | WBGene00012565 |
This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
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fog-2 | Y113G7B.5 | WBGene00001482 |
fog-2 encodes a protein that contains an N-terminal F-box and a C-terminal FOG-2 homology (FTH) domain; during germline development, FOG-2 activity is required for the brief period of hermaphrodite spermatogenesis that occurs during the L3/L4 larval stages; in promoting the onset of spermatogenesis, FOG-2 interacts with the RNA-binding protein GLD-1 which, in turn, binds the tra-2 mRNA 3' untranslated region to repress tra-2 activity in the germline; FOG-2 interacts with GLD-1 through the diverged C-terminal FTH domain, a domain that is both necessary and sufficient to confer GLD-1 binding; polyclonal antibodies raised against FOG-2 indicate that it is a cytoplasmic protein expressed solely in the germline from the L1 larval stage until young adulthood; during earlier larval stages, FOG-2 is detected uniformly throughout the germline, while in L4 larvae and in adult hermaphrodites and males, FOG-2 is found in proliferating and meiotic prophase germ cells.
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hop-1 | C18E3.8 | WBGene00001985 |
hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex.
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immt-2 | W06H3.1 | WBGene00012315 | View | |
inx-22 | Y47G6A.2 | WBGene00002144 | View | |
K08F4.3 | K08F4.3 | WBGene00010678 | View | |
kbp-4 | Y92C3B.1 | WBGene00022357 | View | |
lrr-1 | F33G12.4 | WBGene00018016 |
F33G12.4 encodes a leucine rich repeat-containing protein; loss of F33G12.4 activity via large-scale RNAi indicates that F33G12.4 is essential for embryonic and larval development.
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lst-1 | T22A3.3 | WBGene00003083 |
lst-1 encodes an unfamiliar protein with no known homologs outside of nematodes; in two-hybrid assays, LST-1 does not interact with control baits, but does interact with GPA-6, LAG-1, MPK-1 and K06A1.4, suggesting broad or unspecific interaction activity; however, T22A3.3 solely binds the normal form of GPA-6, without binding its constitutively active mutant form; LST-1 is expressed in head neurons (AWB, ADF, ASG, various interlabial sensory), socket cells, sheath cells in the nose tip, pharyngeal muscle, and intestine; LST-1 has no obvious function or phenotype in RNAi assays.
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mei-1 | T01G9.5 | WBGene00003183 |
mei-1 encodes, by alternative splicing, two slightly different isoforms of an ortholog of the catalytic subunit of katanin (OMIM:606696) that is required for oocyte meiotic spindle formation, for stable association of the meiosis I spindle with the oocyte cortex, and for microtubule severing; MEI-1 exists in a physical complex with MEI-2 at the polar ends of meiotic spindle microtubules and meiotic chromatin; MEI-1 must be inactivated for meiosis to give way to mitosis, and ectopic expression of MEI-1/MEI-2 during mitosis is normally lethal; MEI-1 is bound by the BTB protein MEL-26 (both in vivo and in vitro), which physically links MEI-1 to CUL-3 (an E3 ubiquitin ligase); CUL-3, in turn, promotes MEI-1 proteolysis by the 26S proteasome during the transition from meiosis to mitosis; the MEI-1/MEI-2 complex requires tubules containing the germline-enriched beta tubulin TBB-2 in vivo, but does not require tubules made from TBB-2's (superficially) redundant paralog TBB-1.
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msh-2 | H26D21.2 | WBGene00003418 |
The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
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mut-2 | K04F10.6 | WBGene00003499 |
mut-2 encodes a nucleotidyltransferase that is a member of the polymerase beta nucleotidyltransferase superfamily that includes poly(A) polymerases, 2-5 oligoadenylate synthetases, C. elegans GLD-2, and S. cerevisiae Trf4p; MUT-2 activity is required for meiotic chromosome segregation, negative regulation of DNA transposition, non-transgene-induced RNAi (i.e. RNAi via feeding is affected, whereas RNAi via expression of sense and antisense RNA from a transgene is not), fertility, and viability; analysis of siRNA levels in mut-2 mutant animals indicates that during RNAi, MUT-2 activity is required at a point upstream of siRNA accumulation; neither the precise mechanistic role of MUT-2 in posttranscriptional silencing, nor the MUT-2 expression pattern, is yet known; although it is homologous to GLD-2, CID-1, and related polynucleotide polymerases, MUT-2 neither promotes mRNA translation nor exhibits poly(A) or poly(U) activity on mRNA substrates when tested in Xenopus oocytes.
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mxl-1 | T19B10.11 | WBGene00003509 |
mxl-1 encodes a basic helix-loop-helix protein similar to the vertebrate MAX transcriptional regulators; in vitro, MXL-1 can heterodimerize, and bind an E-box DNA sequence, with MDL-1, a C. elegans MAD-like bHLH protein; mxl-1::gfp reporter fusions are expressed in the posterior intestine and in head and tail neurons.
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nduf-2.2 | T26A5.3 | WBGene00006463 |
T26A5.3 encodes a predicted mitochondrial protein whose mature sequence has near-identity (95%) to GAS-1; T26A5.3 transcription is detectable by RT-PCR, but not visible by promoter-GFP fusion; however, a transgene containing a fusion of the gas-1 promoter to the T26A5.3 protein-coding sequence is able to fully rescue gas-1 mutants, indicating that T26A5.3 encodes a fully functional mitochondrial 49 kDa subunit that may rescue gas-1(fc21) mutants from lethality; mutants homozygous for a T26A5.3 deletion have normal anesthetic sensitivity and normal sensitivity to oxygen (unlike gas-1 mutants) but a shortened lifespan at normal laboratory oxygen levels (20%); animals doubly mutant for gas-1 and T26A5.3 have maternal-effect lethality, but sterile surviving parents are abnormally long-lived (2.7 times longer than wild-type and 4.2 times longer than gas-1 mutants); double mutants remain hypersensitive to oxygen.
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nxf-2 | C15H11.6 | WBGene00003835 |
nxf-2 encodes a predicted homolog of human TAP protein, a member of the NXF family of shuttling transport receptors for nuclear export of mRNA, and it affects embryonic viability.
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R02F2.4 | R02F2.4 | WBGene00019833 |
R02F2.4 encodes a protein with six chitin-binding peritrophin-A domains; R02F2.4 transcripts are enriched during oogenesis; like CEJ-1 and CPG-2, R02F2.4 might participate in eggshell synthesis and early embryonic development, and R02F2.4's multiple peritrophin-A domains might enable mechanical cross-linking of chitin; however, R02F2.4 has no obvious function in mass RNAi assays; while R02F2.4 is more closely similar to CPG-2 than CEJ-1, it may be less strongly expressed (since it has substantially fewer ESTs) and thus be less important in development.
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rod-1 | F55G1.4 | WBGene00018900 | View | |
sep-1 | Y47G6A.12 | WBGene00004775 |
The sep-1 gene encodes a homolog of separase, a protease that splits segregating chromosomes at their centromeres during anaphase by proteolyzing the Scc1 subunit of cohesin.
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syn-4 | T01B11.3 | WBGene00006374 |
syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
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T09B4.1 | T09B4.1 | WBGene00020375 | View | |
T19B10.6 | T19B10.6 | WBGene00011834 | View | |
T21B10.4 | T21B10.4 | WBGene00011886 | View | |
T24H7.4 | T24H7.4 | WBGene00020783 | View | |
taf-11.2 | K10D3.3 | WBGene00006394 | View | |
tbp-1 | T20B12.2 | WBGene00006542 |
tbp-1 encodes the C. elegans ortholog of the human TATA-box-binding protein (TBP; OMIM:600075; mutated in spinocerebellar ataxia 17); consistent with its proposed role in transcriptional regulation, TBP-1 has been shown to provide TFIID-like basal transcription activity in human and C. elegans extracts, to bind specifically to a TATA box sequence, and to interact with TFIIA and TFIIB transcription factors from other species; large-scale RNA-mediated interference (RNAi) screens indicate that tbp-1 activity is required for embryonic and larval development, as well as for normal rates of postembryonic growth.
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Y37E11AL.3 | Y37E11AL.3 | WBGene00021359 | View | |
Y39E4B.2 | Y39E4B.2 | WBGene00012715 | View | |
Y39E4B.5 | Y39E4B.5 | WBGene00012716 | View | |
Y49E10.4 | Y49E10.4 | WBGene00013030 | View | |
ZC302.2 | ZC302.2 | WBGene00013862 | View | |
ZK688.9 | ZK688.9 | WBGene00022803 |
ZK688.9 encodes the C. elegans ortholog of TIP41, a protein first identified in Saccharomyces cerevisiae that physically interacts with and negatively regulates activity of TAP42, a protein phosphatase 2A regulatory subunit; ZK688.9(RNAi) in wild-type animals results in fertility defects in F1 hermaphrodites, who exhibit a 80-90% decrease in the total number of eggs laid, and ~80% embryonic lethality in the F2 generation.
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