Module
- Number
- 233
- Regulatory Genes
- 6
- Module Genes
- 5
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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ekl-4 | Y105E8A.17 | WBGene00013676 | 316 | View | |
ceh-20 | F31E3.1 | WBGene00000443 | 214 |
ceh-20 encodes the C. elegans ortholog of the homeodomain co-factor Extradenticle (Exd/Pbx); together with ceh-40 and unc-62, ceh-20 activity is required for embryonic viability; ceh-20 is also required as a cofactor for LIN-39- and MAB-5- dependent postembryonic mesoderm patterning; in addition, ceh-20 is required for regulating post-embryonic migrations of the Q neuroblast descendants and for regulating vulval development; a CEH-20::GFP fusion protein is expressed in embryos and postembryonically in many cell types including the Q, P, and V cells and their descendants; CEH-20 localizes to the nucleus.
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cey-1 | F33A8.3 | WBGene00000472 | 153 |
cey-1 encodes a protein with a cold-shock/Y-box domain that is expressed in early embryonic blastomeres (at the 15-cell stage, i.e., pre-gastrulation), but is normally repressed in early germline blastomeres by PIE-1; it is predicted to be mitochondrial by phylogenetic profiling.
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Y32H12A.4 | Y32H12A.4 | WBGene00021312 | 115 |
Y32H12A.4 encodes an ortholog of various protein phosphatase 1 (PP1) regulatory (inhibitor) subunit 2 proteins; the phosphatase inhibitory activity of recombinant Y32H12A.4 protein has been validated in vitro, with an IC50 of 5 nM versus purified PP1 catalytic subunit; Y32H12A.4 has anomalously low mobility in SDS-PAGE, consistent with the hypothesis that it (like its orthologs) is a naturally disordered protein that uses native flexibility to bind its substrates; Y32H12A.4 is efficiently phosphorylated in vitro by casein kinase II or CDC2/cyclinB, but not by glycogen synthase kinase-3; Y32H12A.4 is required for embryonic development in mass RNAi assays.
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unc-120 | D1081.2 | WBGene00006844 | 112 |
unc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles.
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cid-1 | K10D2.3 | WBGene00019629 | 100 |
cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases.
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CLR Predictions
4 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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abts-1 | F52B5.1 | WBGene00009920 |
abts-1 encodes an anion transporter; when expressed in Xenopus oocytes, ABTS-1 exhibits robust chloride transport, as well as chloride/bicarbonate exchange activity; abts-1 promoter gfp fusions are expressed primarily in neurons and hypodermis, with weak fluorescence also seen in the pharynx and body wall muscle cells.
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hint-1 | F21C3.3 | WBGene00009002 | View | |
K03A1.2 | K03A1.2 | WBGene00019351 | View | |
ubc-7 | F58A4.10 | WBGene00006704 |
ubc-7 encodes an E2 ubiquitin-conjugating enzyme; by homology, UBC-7 is predicted to function in the covalent attachment of ubiquitin molecules to protein substrates via its association with an E3 ubiquitin-protein ligase; loss of ubc-7 activity via large-scale RNAi screens results in no obvious abnormalities.
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Y54F10AM.5 | Y54F10AM.5 | WBGene00021849 | View |