Transcription regulatory networks in Caenorhabditis elegans

Gene

Public Gene Name

mod-5  

Sequence Name

Y54E10BR.7  

WB ID

WBGene00003387  

Description

mod-5 encodes a Na[+],Cl[-]-dependent serotonin transporter that is required for serotonin uptake by neurosecretory motor neurons and for the experience-dependent enhanced slowing response to food; MOD-5 has serotonin transport activity in cell culture, and is a target of the serotonin uptake inhibitor fluoxetine (Prozac) in vivo; MOD-5 is orthologous to the human serotonin transporter (SLC6A4, OMIM:182138, associated with varying levels of neuroticism, introversion, and anxiety).