Module
- Number
- 210
- Regulatory Genes
- 7
- Module Genes
- 5
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
---|---|---|---|---|---|
F47H4.1 | F47H4.1 | WBGene00009834 | 287 | View | |
Y116A8C.22 | Y116A8C.22 | WBGene00013799 | 199 | View | |
nhr-2 | C32F10.6 | WBGene00003601 | 187 |
nhr-2 encodes a member of the nuclear hormone receptor family that is required for embryonic viability and morphogenesis; expressed during embryogenesis.
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ceh-40 | F17A2.5 | WBGene00000461 | 161 |
ceh-40 encodes one of two C. elegans homeodomain proteins homologous to Extradenticle (Exd/Pbx); ceh-40 genetically interacts with ceh-20 and unc-62 during embryonic development: while loss of ceh-40 activity alone results in no significant embryonic lethality, loss of ceh-40 and ceh-20, or ceh-40, ceh-20, and unc-62, results in incompletely penetrant embryonic lethality.
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F28C6.1 | F28C6.1 | WBGene00009202 | 159 |
F28C6.1 encodes an AP-2-like transcription factor that is ~60% identical to that of F28C6.2 which lies immediately adjacent to F28C6.1 on chromosome II; loss of F28C6.1 activity via large-scale RNAi experiments results in embryonic and larval lethality.
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hmp-2 | K05C4.6 | WBGene00001979 | 124 |
hmp-2 encodes a beta-catenin; HMP-2 activity is required during embryonic development for cell adhesion at adherens junctions, cell migration, and body morphogenesis; as a beta-catenin, HMP-2 likely functions solely as part of a cadherin-catenin complex, as in yeast two-hybrid assays, HMP-2 is the only C. elegans beta-catenin that binds HMP-1/alpha-catenin and HMR-1/cadherin; additionally, in the embryo, HMP-2 co-localizes to sites of epithelial cell contacts with HMP-1 and HMR-1/cadherin; however, despite its normal role in embryonic cell adhesion, HMP-2 can activate transcription and when overexpressed in vivo, can partially rescue vulval defects produced by loss of BAR-1/beta-catenin, suggesting that HMP-2 has retained the ability to interact with the Wnt signaling pathway.
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ceh-49 | F17A9.6 | WBGene00017538 | 113 |
ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
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