Module
- Number
- 18
- Regulatory Genes
- 6
- Module Genes
- 46
Regulatory Genes
Public Gene Name | Sequence Name | WB ID | Weight | Description | Actions |
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nhr-219 | T19A5.5 | WBGene00020555 | 514 | View | |
nhr-172 | C54F6.9 | WBGene00016927 | 241 | View | |
F40G9.14 | F40G9.14 | WBGene00018248 | 153 | View | |
F58G1.2 | F58G1.2 | WBGene00010264 | 114 | View | |
spr-1 | D1014.8 | WBGene00005006 | 109 |
spr-1 encodes the C. elegans ortholog of the human corepressor CoREST that functions in HDAC-containing complexes to mediate transcriptional repression; in C. elegans, spr-1 was first identified in screens for genetic suppressors of the egg-laying defective phenotype of sel-12/presenilin mutants; subsequent genetic analyses showed that spr-1 likely functions as a negative regulator of LIN-12/Notch signaling in multiple cells, including those of the somatic gonad, vulva, and early embryo; spr-1 also interacts genetically with sem-5 to regulate postembryonic growth rates and lin-35Rb to regulate vulval morphogenesis and germline proliferation; in binding assays and yeast two-hybrid experiments, SPR-1 interacts with SPR-5, the C. elegans ortholog of the LSD1 histone demethylase; an SPR-1::MYC fusion protein expressed under the control of the cog-2 promoter localizes to the nucleus and shows increased staining in nuclear speckles and what appears to be the nucleolus.
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mbf-1 | H21P03.1 | WBGene00003148 | 101 | View |
CLR Predictions
10 are found.Module Genes
Public Gene Name | Sequence Name | WB ID | Description | Actions |
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C04E6.11 | C04E6.11 | WBGene00015425 | View | |
C24H11.5 | C24H11.5 | WBGene00007702 | View | |
C25H3.8 | C25H3.8 | WBGene00016117 | View | |
C32E8.9 | C32E8.9 | WBGene00016325 | View | |
cblc-1 | ZK546.17 | WBGene00022766 | View | |
clp-7 | Y77E11A.11 | WBGene00000547 |
clp-7 encodes a member of the calpain family of cysteine proteases.
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eat-3 | D2013.5 | WBGene00001134 |
The eat-3 gene encodes a mitochondrial dynamin-related protein, closely related to bacterial dynamin-like proteins, that is orthologous to human OPA1 (OMIM:203740, mutated in autosomal dominant optic atrophy); EAT-3 is localized to the mitochondrial matrix and may play a role in regulating inner mitochondrial membrane morphology; EAT-3 is expressed in body wall muscle, intestine, and neurons, all tissues with high metabolic rates.
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ero-1 | Y105E8B.8 | WBGene00001334 |
ero-1 encodes an endoplasmic reticulum oxidoreductase that affects ER-stress response and affects reactive oxygen species levels.
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F11A10.6 | F11A10.6 | WBGene00008687 | View | |
F12A10.8 | F12A10.8 | WBGene00017397 | View | |
F33G12.5 | F33G12.5 | WBGene00018017 | View | |
F33H2.6 | F33H2.6 | WBGene00009369 | View | |
F45F2.10 | F45F2.10 | WBGene00018482 | View | |
F46F11.9 | F46F11.9 | WBGene00018512 |
F46F11.9 encodes an ortholog of S. cerevisiae GSG1, involved in intracellular transport and meiosis; F46F11.9 shares an operon with vha-10, and thus might be a previously undescribed V-ATPase component or ancillary protein.
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F48C1.6 | F48C1.6 | WBGene00018599 | View | |
F54A3.6 | F54A3.6 | WBGene00018785 | View | |
F57A8.2 | F57A8.2 | WBGene00010178 | View | |
gob-1 | H13N06.3 | WBGene00001649 |
gob-1 encodes an experimentally confirmed trehalose-6-phosphatase, which belongs to the HAD-like hydrolase superfamily; heat-shock induction of transgenic ELT-2 causes ectopic expression of gob-1; gob-1 first has ELT-2-dependent expression in the 8E cell stage of embryonic intestine, but later is expressed more widely; gob-1 mutants are lethal as early larvae, at least partly because of their intestines being constricted by the end of embryonic development, but some gob-1 mutants die even with an open intestine; strong loss-of-function mutations in two trehalose-6-phosphate synthases (tps-1 and tps-2) completely suppress gob-1 lethality, indicating that gob-1 mutant lethality is due to a toxic accumulation of trehalose-6-phosphate.
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K08E4.6 | K08E4.6 | WBGene00010670 | View | |
mtm-1 | Y110A7A.5 | WBGene00003475 |
mtm-1 encodes a myotubularin orthologous to human MTM1 (OMIM:300415, mutated in myotubular myopathy), MTMR1 (OMIM:300171), and MTMR2 (OMIM:603557, mutated in type 4B1 Charcot-Marie-Tooth disease); mtm-1(RNAi)suppresses the endocytosis defect of let-512 mutants, indicating that MTM-1 negatively regulates LET-512 (a phosphatidylinositol 3-kinase orthologous to yeast Vps34).
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pcs-1 | F54D5.1 | WBGene00003960 | View | |
pmr-1 | ZK256.1 | WBGene00004063 |
The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600).
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pqn-96 | ZK1236.6 | WBGene00004175 |
The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
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R05F9.1 | R05F9.1 | WBGene00019888 | View | |
ral-1 | Y53G8AR.3 | WBGene00021811 | View | |
smg-3 | Y73B6BL.18 | WBGene00004881 | View | |
smg-6 | Y54F10AL.2 | WBGene00004884 | View | |
sphk-1 | C34C6.5 | WBGene00007918 | View | |
T27F6.6 | T27F6.6 | WBGene00012105 | View | |
tsr-1 | F53G2.6 | WBGene00006647 |
tsr-1 encodes a homolog of human transportin-SR, a nuclear transport receptor, and affects embryonic viability.
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ubc-16 | Y54E5B.4 | WBGene00006711 | View | |
vps-35 | F59G1.3 | WBGene00006933 | View | |
W02B12.11 | W02B12.11 | WBGene00012206 | View | |
Y105E8A.2 | Y105E8A.2 | WBGene00013667 | View | |
Y111B2A.10 | Y111B2A.10 | WBGene00013734 | View | |
Y39A1A.20 | Y39A1A.20 | WBGene00012657 | View | |
Y45G12B.2 | Y45G12B.2 | WBGene00021563 | View | |
Y48B6A.13 | Y48B6A.13 | WBGene00012984 | View | |
Y51H7C.5 | Y51H7C.5 | WBGene00021783 | View | |
Y62E10A.6 | Y62E10A.6 | WBGene00013376 | View | |
Y73F8A.24 | Y73F8A.24 | WBGene00013529 | View | |
Y75B8A.24 | Y75B8A.24 | WBGene00013557 | View | |
Y87G2A.11 | Y87G2A.11 | WBGene00013599 | View | |
Y95D11A.1 | Y95D11A.1 | WBGene00013605 | View | |
ZK1010.2 | ZK1010.2 | WBGene00014176 | View | |
ZK524.4 | ZK524.4 | WBGene00013994 | View |